Ovarian reserve, antibody anti-corpus luteum and lower genital tract infection in adult women with systemic lupus erythematosus, Behçet's syndrome and Takayasu's arteritis

• Grant number: 11/12471-2
• Support Opportunities: Regular Research Grants
• Start date: March 01, 2012
• End date: February 28, 2014
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Clovis Artur Almeida da Silva
• Grantee: Clovis Artur Almeida da Silva
• Host Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated researchers: Andrea Rocha de Saboia Mont Alverne ; Daniel Brito de Araujo ; Eloisa Silva Dutra de Oliveira Bonfá ; Lucas Yugo Shiguehara Yamakami ; Rosa Maria Rodrigues Pereira ; Sandra Gofinet Pasoto ; Vilma dos Santos Trindade Viana

Abstract

Systemic lupus erythematosus (SLE) is an autoimmune disease of connective tissue, multisystemic. Behcet's syndrome (BS) and Takayasu's arteritis (TA) are inflammatory diseases of unknown etiology, classified as primary vasculitis, and may involve several organs. These three diseases affect women of reproductive age, which raises questions related to gonadal function in these patients. While much attention has been given to ovarian failure related to immunosuppressive therapy, little is known about ovarian reserve and the presence of autoantibodies anti-ovarian in these diseases. Objectives: to evaluate ovarian reserve, lower genital tract infection and the presence of antibody anti-corpus luteum in adult women with SLE, SB and TA, and its possible associations with demographic data, clinical manifestations, disease activity, cumulative damage and treatment. Methods: we will study 80 adult women in reproductive age with SLE, 40 with SB and 40 with AT, comparing them with a control group of 80 healthy women. We will assess demographic data, clinical manifestations of disease, laboratory findings and treatments. Hormonal evaluations and ovarian reserve will be determined by the measure of: follicle stimulating hormone, luteinizing hormone, estradiol, progesterone, prolactin, testosterone, inhibin A and B and anti-Mullerian hormone. We also will perform the dosage of antibody anti-corpus luteum, transvaginal ultrasound and HPV and Chlamydia search. (AU)

Scientific publications

(31)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

SILVA, C. A.; COCUZZA, M.; CARVALHO, J. F.; BONFA, E.. Diagnosis and classification of autoimmune orchitis. AUTOIMMUNITY REVIEWS, v. 13, n. 4-5, SI, p. 431-434, APR-MAY 2014. (08/58238-4, 11/12471-2)

DE ARAUJO, D. B.; YAMAKAMI, L. Y. S.; AIKAWA, N. E.; BONFA, E.; VIANA, V. S. T.; PASOTO, S. G.; PEREIRA, R. M. R.; SERAFIN, P. C.; BORBA, E. F.; SILVA, C. A.. Ovarian reserve in adult patients with childhood-onset lupus: a possible deleterious effect of methotrexate?. SCANDINAVIAN JOURNAL OF RHEUMATOLOGY, v. 43, n. 6, p. 503-511, 2014. (11/12471-2)

SOFIA S. MARTINS; IZABEL M. BUSCATTI; PRICILLA S. FREIRE; ERICA G. CAVALCANTE; ADRIANA M. SALLUM; LUCIA M.A. CAMPOS; CLOVIS A. SILVA. Doença de Kikuchi-Fujimoto antes do diagnóstico de lúpus eritematoso sistêmico juvenil. REVISTA BRASILEIRA DE REUMATOLOGIA, v. 54, n. 5, p. 400-403, 2014-10-00. (08/58238-4, 11/12471-2)

DANIELA MR LOURENÇO; IZABEL M BUSCATTI; BENITO LOURENÇO; FERNANDA C MONTI; JOSÉ ALBINO PAZ; CLOVIS A SILVA. Neurite óptica em paciente com artrite idiopática juvenil. REVISTA BRASILEIRA DE REUMATOLOGIA, v. 54, n. 6, p. 486-489, 2014-12-00. (08/58238-4, 11/12471-2)

MARQUES, VICTOR L. S.; GUARIENTO, ANDRESSA; SIMOES, MARLISE S. M.; BLAY, GABRIELA; LOTITO, ANA PAOLA N.; SILVA, CLOVIS A.. Childhood-onset systemic polyarteritis nodosa and systemic lupus erythematosus: an overlap syndrome?. Revista Brasileira de Reumatologia, v. 56, n. 6, p. 551-553, NOV-DEC 2016. (08/58238-4, 11/12471-2)

DE SOUZA, F. H. C.; SHINJO, S. K.; YAMAKAMI, L. Y. S.; VIANA, V. S. T.; BARACAT, E. C.; BONFA, E.; SILVA, C. A.. Reduction of ovarian reserve in adult patients with dermatomyositis. CLINICAL AND EXPERIMENTAL RHEUMATOLOGY, v. 33, n. 1, p. 44-49, JAN-FEB 2015. (11/12471-2, 11/15609-5)

LEAL, G. N.; SILVA, K. F.; FRANCA, C. M. P.; LIANZA, A. C.; ANDRADE, J. L.; CAMPOS, L. M. A.; BONFA, E.; SILVA, C. A.. Subclinical right ventricle systolic dysfunction in childhood-onset systemic lupus erythematosus: insights from two-dimensional speckle-tracking echocardiography. Lupus, v. 24, n. 6, p. 613-620, MAY 2015. (11/12471-2)

VIOLA, GABRIELA R.; GIACOMIN, MARIA FERNANDA A.; FRANCA, CAMILA M. P.; SALLUM, ADRIANA M. E.; JACOB, CRISTINA M. A.; SILVA, CLOVIS A.. Chronic polyarthritis as isolated manifestation of toxocariasis. Revista Brasileira de Reumatologia, v. 56, n. 2, p. 185-187, MAR-APR 2016. (08/58238-4, 11/12471-2)

LUBE, GABRIELLA E.; AIKAWA, NADIA E.; TACLA, MARICY; LEAL, MARTA M.; LOURENCO, BENITO; SILVA, LUIZ E. V.; QUEIROZ, LIGIA B.; BARACAT, EDMUND C.; SILVA, CLOVIS A.. Condyloma acuminatum in childhood-systemic lupus erythematosus patients. ACTA REUMATOLOGICA PORTUGUESA, v. 39, n. 2, p. 182-187, APR-JUN 2014. (11/12471-2)

LOURENCO, D. M. R.; GOMES, R. CUNHA; AIKAWA, N. E.; CAMPOS, L. M. A.; ROMITI, R.; SILVA, C. A.. Childhood-onset bullous systemic lupus erythematosus. Lupus, v. 23, n. 13, p. 1422-1425, NOV 2014. (08/58238-4, 11/12471-2)

SILVA, CLOVIS A.; AIKAWA, NADIA E.; BONFA, ELOISA. Vaccinations in juvenile chronic inflammatory diseases: an update. Nature Reviews Rheumatology, v. 9, n. 9, p. 532-543, SEP 2013. (08/58238-4, 11/12471-2, 10/10749-0)

FRANCA, CAMILA M. P.; CAVALCANTE, ERICA G.; RIBEIRO, ALINE S. M.; OLIVEIRA, GUILHERME T.; LITVINOV, NADIA; SILVA, CLOVIS A.. Disseminated histoplasmosis in a juvenile lupus erythematosus patient. ACTA REUMATOLOGICA PORTUGUESA, v. 37, n. 3, p. 276-279, JUL-SEP 2012. (11/12471-2)

SILVA, CLOVIS A.; AVCIN, TADEJ; BRUNNER, HERMINE I.. Taxonomy for systemic lupus erythematosus with onset before adulthood. ARTHRITIS CARE & RESEARCH, v. 64, n. 12, p. 1787-1793, DEC 2012. (11/12471-2)

MARQUES, V. L. S.; GOMES, R. C.; VIOLA, G. R.; MAIA, M. M.; DURIGON, G. S.; AIKAWA, N. E.; SILVA, C. ARTUR. Pulmonary cryptococcosis in childhood systemic lupus erythematosus and Sjogren syndrome overlap: a rare opportunistic infection. Lupus, v. 22, n. 13, p. 1409-1412, NOV 2013. (08/58238-4, 11/12471-2)

MOORTHY, L. N.; SAAD-MAGALHAES, C.; OLIVEIRA SATO, J.; LEN, C. A.; BRANDAO VASCO, M.; APPENZELLER, S.; MARINI, R.; FEITOSA DE OLIVEIRA, S. K.; RODRIGUES, M.; SZTAJNBOK, F.; et al. Validation of the Portuguese Simple Measure of Impact of Lupus Erythematosus in Youngsters (SMILEY) in Brazil. Lupus, v. 22, n. 2, p. 190-197, FEB 2013. (08/58238-4, 11/12471-2, 08/02917-0)

YAMAKAMI, L. Y. S.; SERAFINI, P. C.; DE ARAUJO, D. B.; BONFA, E.; LEON, E. P.; BARACAT, E. C.; SILVA, C. A.. Ovarian reserve in women with primary antiphospholipid syndrome. Lupus, v. 23, n. 9, p. 862-867, AUG 2014. (11/12471-2)

BENITO LOURENÇO; KATIA T. KOZU; GABRIELA N. LEAL; MARCO F. SILVA; ELISABETH G.C. FERNANDES; CAMILA M.P. FRANÇA; FERNANDO H.C. SOUZA; CLOVIS A. SILVA. Contracepção para adolescentes com doenças reumáticas crônicas. REVISTA BRASILEIRA DE REUMATOLOGIA, v. 57, n. 1, p. 73-81, 2017-02-00. (14/14806-0, 11/12471-2)

SILVA, C. A.; YAMAKAMI, L. Y. S.; AIKAWA, N. E.; ARAUJO, D. B.; CARVALHO, J. F.; BONFA, E.. Autoimmune primary ovarian insufficiency. AUTOIMMUNITY REVIEWS, v. 13, n. 4-5, p. 4-pg., 2014-04-01. (11/12471-2, 08/58238-4)

SILVA, C. A.; COCUZZA, M.; CARVALHO, J. F.; BONFA, E.. Diagnosis and classification of autoimmune orchitis. AUTOIMMUNITY REVIEWS, v. 13, n. 4-5, p. 4-pg., 2014-04-01. (11/12471-2, 08/58238-4)

SILVA, C. A.; YAMAKAMI, L. Y. S.; AIKAWA, N. E.; ARAUJO, D. B.; CARVALHO, J. F.; BONFA, E.. Autoimmune primary ovarian insufficiency. AUTOIMMUNITY REVIEWS, v. 13, n. 4-5, SI, p. 427-430, APR-MAY 2014. (08/58238-4, 11/12471-2)

CARLOS DE SOUZA, FERNANDO HENRIQUE; DA SILVA, CLOVIS ARTUR; SHIGUEHARA YAMAKAMI, LUCAS YUGO; TRINDADE VIANA, VILMA DOS SANTOS; BONFA, ELOISA; SHINJO, SAMUEL KATSUYUKI. Reduced ovarian reserve in patients with adult polymyositis. CLINICAL RHEUMATOLOGY, v. 34, n. 10, p. 1795-1799, OCT 2015. (11/12471-2, 11/15609-5)

MONT'ALVERNE, ANDREA ROCHA S.; PEREIRA, ROSA MARIA R.; YAMAKAMI, LUCAS YUGO S.; VIANA, VILMA SANTOS T.; BARACAT, EDMUND CHADA; BONFA, ELOISA; SILVA, CLOVIS ARTUR. Reduced Ovarian Reserve in Patients with Takayasu Arteritis. JOURNAL OF RHEUMATOLOGY, v. 41, n. 10, p. 2055-2059, OCT 2014. (11/12471-2)

PRISCILA ARAÚJO; MÁRCIO GUILHERME NUNES CARVALHO; MARLON VAN WEELDEN; BENITO LOURENÇO; LÍGIA BRUNI QUEIROZ; CLOVIS ARTUR SILVA. Uso indevido de drogas e função sexual em adolescentes com doenças crônicas. Revista Paulista de Pediatria, v. 34, n. 3, p. 323-329, 2016-09-00. (14/14806-0, 11/12471-2)

MARLON VAN WEELDEN; BENITO LOURENÇO; GABRIELA R. VIOLA; NADIA E. AIKAWA; LÍGIA B. QUEIROZ; CLOVIS A. SILVA. Uso de substâncias e função sexual na artrite idiopática juvenil. REVISTA BRASILEIRA DE REUMATOLOGIA, v. 56, n. 4, p. 323-329, 2016-08-00. (11/12471-2)

BUSCATTI, IZABEL M.; GIACOMIN, MARIA FERNANDA A.; SILVA, MARCO FELIPE C.; CAMPOS, LUCIA M. A.; SALLUM, ADRIANA M. E.; SILVA, CLOVIS A.. Laryngotracheal stenosis requiring emergency tracheostomy as the first manifestation of childhood-relapsing polychondritis. ACTA REUMATOLOGICA PORTUGUESA, v. 38, n. 3, p. 208-211, JUL-SEP 2013. (08/58238-4, 11/12471-2)

GUARIENTO, ANDRESSA; SILVA, MARCO FELIPE C.; TASSETANO, PRISCILLA S. F.; ROCHA, SILVIA MARIA S.; CAMPOS, LUCIA M. A.; VALENTE, MARCELO; SILVA, CLOVIS A.. Liver and spleen biometrics in childhood-onset systemic lupus erythematosus patients. Revista Brasileira de Reumatologia, v. 55, n. 4, p. 346-351, JUL-AUG 2015. (11/12471-2)

MARLON VAN WEELDEN; LÍGIA B. QUEIROZ; DANIELA M.R. LOURENÇO; KATIA KOZU; BENITO LOURENÇO; CLOVIS A. SILVA. Uso de álcool, tabaco e drogas ilícitas por pacientes com lúpus eritematoso sistêmico pediátrico. REVISTA BRASILEIRA DE REUMATOLOGIA, v. 56, n. 3, p. 228-234, 2016-06-00. (11/12471-2)

LOURENCO, BENITO; KOZU, KATIA T.; LEAL, GABRIELA N.; SILVA, MARCO F.; FERNANDES, ELISABETH G. C.; FRANCA, CAMILA M. P.; SOUZA, FERNANDO H. C.; SILVA, CLOVIS A.. Contraception for adolescents with chronic rheumatic diseases. Revista Brasileira de Reumatologia, v. 57, n. 1, p. 73-81, JAN-FEB 2017. (14/14806-0, 11/12471-2)

WAISBERG, MARIANA G.; RIBEIRO, ANA C. M.; CANDIDO, WELLINGTON M.; MEDEIROS, POLIANA B.; MATSUZAKI, CEZAR N.; BELDI, MARIANA C.; TACLA, MARICY; CAIAFFA-FILHO, HELIO H.; BONFA, ELOISA; SILVA, CLOVIS A.. Human papillomavirus and chlamydia trachomatis infections in rheumatoid arthritis under anti-TNF therapy: an observational study. RHEUMATOLOGY INTERNATIONAL, v. 35, n. 3, p. 459-463, MAR 2015. (11/12471-2)

GABRIELA BLAY; MARIANA P.L. FERRIANI; IZABEL M. BUSCATTI; CAMILA M.P. FRANÇA; LUCIA M.A. CAMPOS; CLOVIS A. SILVA. Piomiosite no lúpus eritematoso sistêmico juvenil. REVISTA BRASILEIRA DE REUMATOLOGIA, v. 56, n. 1, p. 79-81, 2016-02-00. (08/58238-4, 11/12471-2)

ANDRESSA GUARIENTO; MARCO FELIPE C. SILVA; PRISCILLA S.F. TASSETANO; SÍLVIA MARIA S. ROCHA; LÚCIA M.A. CAMPOS; MARCELO VALENTE; CLOVIS A. SILVA. Biometria do fígado e do baço em pacientes com lúpus eritematoso sistêmico de início pediátrico. REVISTA BRASILEIRA DE REUMATOLOGIA, v. 55, n. 4, p. 346-351, 2015-08-00. (11/12471-2)