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Using systems biology approach to develop a model for whole plant functioning

Grant number: 11/52065-3
Support type:Research Grants - Research Partnership for Technological Innovation - PITE
Duration: October 01, 2012 - March 31, 2017
Field of knowledge:Biological Sciences - Botany
Cooperation agreement: Microsoft Research
Principal Investigator:Marcos Silveira Buckeridge
Grantee:Marcos Silveira Buckeridge
Home Institution: Instituto de Biociências (IB). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Company: Microsoft
City: São Paulo
Partner institutions: Microsoft
Associated grant(s):13/50316-4 - Impact of elevated CO2 and drought on metabolism of Sorghum, AP.R
Associated scholarship(s):15/13479-8 - Using systems biology approach to develop a model for whole plant functioning, BP.PD
13/24205-0 - Development of a bioinformatic tool for integration of transcriptomics, proteomics and physiology using sorghum and sugarcane as model systems, BP.DR


The advance of the sciences of the global climate changes and bioenergy require deep understanding of how plants work in a changing environment. Although model and native plants have been studied from the viewpoint of their ecophysiology, biochemistry and molecular biology, these levels of organization have not been approached in an integrated way. The limitation is the enormous amounts of data produced. This proposal aims at understanding the interaction among the different organizational levels through analysis of a data set from a C4 model plant (sorghum) cultivated at elevated CO2 combined with water deficit. We intend to obtain data on the physiology, metabolism and gene expression of sorghum grown in four different conditions: 1) ambient [CO2] well watered; 2) elevated [CO2] well watered; 3) ambient [CO2] with water deficit and 4) elevated [CO2] with water deficit. Two groups of plant sciences, will interact with one group of mathematics and computing sciences to reach the following goals: 1) test and refine tools for network analysis in biology; 2) develop tools for the integration of data from different experiments: 3) develop data visualization tools; 4) attempts to extrapolate to other species. (AU)

Articles published in Agência FAPESP Newsletter about the research grant
Software compares more than two complex networks simultaneously 
High concentration of CO2 protects sorghum against drought and improves seeds 
Articles published in other media outlets (7 total):
More itemsLess items
Software Compares More Than Two Complex Networks Simultaneously 
Un software permite comparar más de dos redes complejas a la vez 
Un software permite comparar más de dos redes complejas a la vez 
Un software permite comparar más de dos redes complejas a la vez 
Un software permite comparar más de dos redes complejas a la vez 
Software pretende desenvolver uma forma diferente de abordar o mundo 
Software permite comparar mais de duas redes complexas simultaneamente 

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
LOCOSSELLI, GIULIANO MASELLI; BUCKERIDGE, MARCOS SILVEIRA. Dendrobiochemistry, a missing link to further understand carbon allocation during growth and decline of trees. TREES-STRUCTURE AND FUNCTION, v. 31, n. 6, p. 1745-1758, DEC 2017. Web of Science Citations: 11.
TAVARES, EVELINE Q. P.; BUCKERIDGE, MARCOS S. Do plant cell walls have a code?. Plant Science, v. 241, p. 286-294, DEC 2015. Web of Science Citations: 9.
DE SOUZA, AMANDA P.; COCURON, JEAN-CHRISTOPHE; GARCIA, ANA CAROLINA; ALONSO, ANA PAULA; BUCKERIDGE, MARCOS S. Changes in Whole-Plant Metabolism during the Grain-Filling Stage in Sorghum Grown under Elevated CO2 and Drought. Plant Physiology, v. 169, n. 3, p. 1755-1765, NOV 2015. Web of Science Citations: 13.

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