Evaluation of hematopoietic stem cell treatment in dogs with chronic renal failure

• Grant number: 10/19012-0
• Support Opportunities: Research Projects - Thematic Grants
• Start date: June 01, 2012
• End date: May 31, 2018
• Field of knowledge: Health Sciences - Medicine
• Principal Investigator: Lucia da Conceição Andrade
• Grantee: Lucia da Conceição Andrade
• Host Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Pesquisadores principais:( Últimos ): Marcia Mery Kogika
• Pesquisadores principais:( Antigos ): Niels Olsen Saraiva Câmara
• Associated scholarship(s): 15/21308-9 - Mesenchymal stem cells derived from Wharton's Jelly in cardiopulmonary injury and systemic neuroimmunomodulation in sepsis, BP.DR; 13/09179-3 - Evaluation of mesenchymal stem cells from human umbilical cord on organ damage and endothelial dysfunction in sepsis, BP.MS

Abstract

There are currently few therapies available to prevent the progression of renal disease in humans or animals. To date, the only strategies that have been recommended are angiotensin-converting enzyme inhibitor use, blood pressure control, and a reduction in dietary protein. Chronic renal failure (CRF) in dogs is very similar to that seen in humans, especially in terms of the pathophysiological aspects, and CRF is being diagnosed with increasing frequency in dogs. Despite advances in the treatment of canine CRF, animals reaching the advanced stages of the disease are routinely euthanized. In a recent study involving an experimental rat model of CRF (5/6 nephrectomy), we showed that treatment with lineage-negative hematopoietic stem cells protects against CRF. In that study, lineage-negative hematopoietic stem cells were injected into the femoral vein on postnephrectomy day 15. On postnephrectomy day 60, treated rats presented reductions in proteinuria, glomerulosclerosis, anemia, renal infiltration of immune cells, and protein expression of monocyte chemoattractant protein -1. On postnephrectomy day 120, renal function (inulin clearance) was significantly better in treated rats than in untreated rats. The hypothesis of the present study was that administration of lineage-negative hematopoietic stem cells can slow the progression of CRF in dogs with stage 2 or 3 disease. The lineage-negative hematopoietic stem cells will be isolated from human umbilical cord blood. (AU)

Scientific publications

(11)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

ANDRADE, LUCIA; RODRIGUES, CAMILA E.; GOMES, SAMIRAH A.; NORONHA, IRENE L.. Acute Kidney Injury as a Condition of Renal Senescence. CELL TRANSPLANTATION, v. 27, n. 5, SI, p. 739-753, MAY 2018. (10/19012-0)

KOLBE, KARIN R.; SANCHES, TALITA R.; FANELLI, CAMILLA; GARNICA, MARGOTH R.; DE CASTRO, LETICIA URBANO; GOOCH, KAREN; THOMAS, STEPHEN; TAYLOR, STEPHEN; GORRINGE, ANDREW; NORONHA, IRENE DE L.; et al. Acute kidney injury in a mouse model of meningococcal disease. INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY, v. 35, DEC 20 2021. (10/19012-0)

CONDOR, JOSE M.; RODRIGUES, CAMILA E.; MOREIRA, ROBERTO DE SOUSA; CANALE, DANIELE; VOLPINI, RILDO A.; SHIMIZU, MARIA H. M.; CAMARA, NIELS O. S.; NORONHA, IRENE DE L.; ANDRADE, LUCIA. Treatment With Human Wharton's Jelly-Derived Mesenchymal Stem Cells Attenuates Sepsis-Induced Kidney Injury, Liver Injury, and Endothelial Dysfunction. STEM CELLS TRANSLATIONAL MEDICINE, v. 5, n. 8, p. 1048-1057, AUG 2016. (13/09179-3, 10/19012-0)

COELHO, FERNANDA OLIVEIRA; JORGE, LECTICIA BARBOSA; DE BRAGANCA VICIANA, ANA CAROLINA; SANCHES, TALITA R.; DOS SANTOS, FERNANDO; HELOU, CLAUDIA M. B.; IRIGOYEN, MARIA CLAUDIA; KURO-O, MAKOTO; ANDRADE, LUCIA. Chronic nicotine exposure reduces klotho expression and triggers different renal and hemodynamic responses in klotho-haploinsufficient mice. AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, v. 314, n. 5, p. F992-F998, MAY 2018. (10/19012-0, 10/08529-2, 12/03025-1)

CHACAR, FERNANDA; KOGIKA, MARCIA; SANCHES, TALITA R.; CARAGELASCO, DOUGLAS; MARTORELLI, CINTHIA; RODRIGUES, CAMILA; CAPCHA, JOSE MANUEL C.; CHEW, DENNIS; ANDRADE, LUCIA. Urinary Tamm-Horsfall protein, albumin, vitamin D-binding protein, and retinol-binding protein as early biomarkers of chronic kidney disease in dogs. PHYSIOLOGICAL REPORTS, v. 5, n. 11, JUN 2017. (10/19012-0)

JORGE, LECTICIA B.; COELHO, FERNANDA O.; SANCHES, TALITA R.; MALHEIROS, DENISE M. A. C.; DE SOUZA, LEANDRO EZAQUIEL; DOS SANTOS, FERNANDO; LIMA, LARISSA DE SA; SCAVONE, CRISTOFORO; IRIGOYEN, MARIA; KURO-O, MAKOTO; et al. Klotho deficiency aggravates sepsis-related multiple organ dysfunction. AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, v. 316, n. 3, p. F438-F448, MAR 2019. (10/19012-0, 12/03025-1, 10/08529-2)

MOREIRA, ROBERTO S.; IRIGOYEN, MARIA C.; CAPCHA, JOSE M. C.; SANCHES, TALITA R.; GUTIERREZ, PAULO S.; GARNICA, MARGOTH R.; NORONHA, IRENE DE L.; ANDRADE, LUCIA. Synthetic apolipoprotein A-I mimetic peptide 4F protects hearts and kidneys after myocardial infarction. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, v. 318, n. 3, p. R529-R544, MAR 2020. (10/19012-0)

CONDOR CAPCHA, JOSE MANUEL; RODRIGUES, CAMILA ELEUTERIO; MOREIRA, ROBERTO DE SOUZA; SILVEIRA, MARCELO DUARTE; DOURADO, PAULO; DOS SANTOS, FERNANDO; IRIGOYEN, MARIA CLAUDIA; JENSEN, LEONARDO; GARNICA, MARGOTH RAMOS; NORONHA, IRENE L.; et al. Wharton's jelly-derived mesenchymal stem cells attenuate sepsis-induced organ injury partially via cholinergic anti-inflammatory pathway activation. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, v. 318, n. 1, p. R135-R147, JAN 2020. (10/19012-0, 15/21308-9)

CONDOR CAPCHA, JOSE MANUEL; MOREIRA, ROBERTO S.; RODRIGUES, CAMILA E.; SILVEIRA, MARCELO A. D.; ANDRADE, LUCIA; GOMES, SAMIRAH A.. Using the Cecal Ligation and Puncture Model of Sepsis to Induce Rats to Multiple Organ Dysfunction. BIO-PROTOCOL, v. 11, n. 7, APR 5 2021. (15/21308-9, 10/19012-0)

DUARTE SILVEIRA, MARCELO AUGUSTO; CONDOR CAPCHA, JOSE MANUEL; SANCHES, TALITA ROJAS; DE SOUSA MOREIRA, ROBERTO; GARNICA, MARGOT S.; SHIMIZU, MARIA HELOISA; BERRETTA, ANDRESA; TELES, FLAVIO; NORONHA, IRENE L.; ANDRADE, LUCIA. Green propolis extract attenuates acute kidney injury and lung injury in a rat model of sepsis. SCIENTIFIC REPORTS, v. 11, n. 1, MAR 15 2021. (10/19012-0)

ANDRADE, LUCIA; RODRIGUES, CAMILA E.; GOMES, SAMIRAH A.; NORONHA, IRENE L.. Acute Kidney Injury as a Condition of Renal Senescence. CELL TRANSPLANTATION, v. 27, n. 5, p. 15-pg., 2018-05-01. (10/19012-0)