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Evaluation of hematopoietic stem cell treatment in dogs with chronic renal failure

Grant number: 10/19012-0
Support type:Research Projects - Thematic Grants
Duration: June 01, 2012 - May 31, 2018
Field of knowledge:Health Sciences - Medicine
Principal Investigator:Lucia da Conceição Andrade
Grantee:Lucia da Conceição Andrade
Home Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Co-Principal Investigators:Marcia Mery Kogika ; Niels Olsen Saraiva Câmara
Associated scholarship(s):15/21308-9 - Mesenchymal stem cells derived from Wharton's Jelly in cardiopulmonary injury and systemic neuroimmunomodulation in sepsis, BP.DR
13/09179-3 - Evaluation of mesenchymal stem cells from human umbilical cord on organ damage and endothelial dysfunction in sepsis, BP.MS

Abstract

There are currently few therapies available to prevent the progression of renal disease in humans or animals. To date, the only strategies that have been recommended are angiotensin-converting enzyme inhibitor use, blood pressure control, and a reduction in dietary protein. Chronic renal failure (CRF) in dogs is very similar to that seen in humans, especially in terms of the pathophysiological aspects, and CRF is being diagnosed with increasing frequency in dogs. Despite advances in the treatment of canine CRF, animals reaching the advanced stages of the disease are routinely euthanized. In a recent study involving an experimental rat model of CRF (5/6 nephrectomy), we showed that treatment with lineage-negative hematopoietic stem cells protects against CRF. In that study, lineage-negative hematopoietic stem cells were injected into the femoral vein on postnephrectomy day 15. On postnephrectomy day 60, treated rats presented reductions in proteinuria, glomerulosclerosis, anemia, renal infiltration of immune cells, and protein expression of monocyte chemoattractant protein -1. On postnephrectomy day 120, renal function (inulin clearance) was significantly better in treated rats than in untreated rats. The hypothesis of the present study was that administration of lineage-negative hematopoietic stem cells can slow the progression of CRF in dogs with stage 2 or 3 disease. The lineage-negative hematopoietic stem cells will be isolated from human umbilical cord blood. (AU)

Scientific publications (7)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
MOREIRA, ROBERTO S.; IRIGOYEN, MARIA C.; CAPCHA, JOSE M. C.; SANCHES, TALITA R.; GUTIERREZ, PAULO S.; GARNICA, MARGOTH R.; NORONHA, IRENE DE L.; ANDRADE, LUCIA. Synthetic apolipoprotein A-I mimetic peptide 4F protects hearts and kidneys after myocardial infarction. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, v. 318, n. 3, p. R529-R544, MAR 2020. Web of Science Citations: 0.
CONDOR CAPCHA, JOSE MANUEL; RODRIGUES, CAMILA ELEUTERIO; MOREIRA, ROBERTO DE SOUZA; SILVEIRA, MARCELO DUARTE; DOURADO, PAULO; DOS SANTOS, FERNANDO; IRIGOYEN, MARIA CLAUDIA; JENSEN, LEONARDO; GARNICA, MARGOTH RAMOS; NORONHA, IRENE L.; ANDRADE, LUCIA; GOMES, SAMIRAH ABREU. Wharton's jelly-derived mesenchymal stem cells attenuate sepsis-induced organ injury partially via cholinergic anti-inflammatory pathway activation. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, v. 318, n. 1, p. R135-R147, JAN 2020. Web of Science Citations: 0.
JORGE, LECTICIA B.; COELHO, FERNANDA O.; SANCHES, TALITA R.; MALHEIROS, DENISE M. A. C.; DE SOUZA, LEANDRO EZAQUIEL; DOS SANTOS, FERNANDO; LIMA, LARISSA DE SA; SCAVONE, CRISTOFORO; IRIGOYEN, MARIA; KURO-O, MAKOTO; ANDRADE, LUCIA. Klotho deficiency aggravates sepsis-related multiple organ dysfunction. AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, v. 316, n. 3, p. F438-F448, MAR 2019. Web of Science Citations: 0.
ANDRADE, LUCIA; RODRIGUES, CAMILA E.; GOMES, SAMIRAH A.; NORONHA, IRENE L. Acute Kidney Injury as a Condition of Renal Senescence. CELL TRANSPLANTATION, v. 27, n. 5, SI, p. 739-753, MAY 2018. Web of Science Citations: 8.
COELHO, FERNANDA OLIVEIRA; JORGE, LECTICIA BARBOSA; DE BRAGANCA VICIANA, ANA CAROLINA; SANCHES, TALITA R.; DOS SANTOS, FERNANDO; HELOU, CLAUDIA M. B.; IRIGOYEN, MARIA CLAUDIA; KURO-O, MAKOTO; ANDRADE, LUCIA. Chronic nicotine exposure reduces klotho expression and triggers different renal and hemodynamic responses in klotho-haploinsufficient mice. AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, v. 314, n. 5, p. F992-F998, MAY 2018. Web of Science Citations: 1.
CHACAR, FERNANDA; KOGIKA, MARCIA; SANCHES, TALITA R.; CARAGELASCO, DOUGLAS; MARTORELLI, CINTHIA; RODRIGUES, CAMILA; CAPCHA, JOSE MANUEL C.; CHEW, DENNIS; ANDRADE, LUCIA. Urinary Tamm-Horsfall protein, albumin, vitamin D-binding protein, and retinol-binding protein as early biomarkers of chronic kidney disease in dogs. PHYSIOLOGICAL REPORTS, v. 5, n. 11 JUN 2017. Web of Science Citations: 3.
CONDOR, JOSE M.; RODRIGUES, CAMILA E.; MOREIRA, ROBERTO DE SOUSA; CANALE, DANIELE; VOLPINI, RILDO A.; SHIMIZU, MARIA H. M.; CAMARA, NIELS O. S.; NORONHA, IRENE DE L.; ANDRADE, LUCIA. Treatment With Human Wharton's Jelly-Derived Mesenchymal Stem Cells Attenuates Sepsis-Induced Kidney Injury, Liver Injury, and Endothelial Dysfunction. STEM CELLS TRANSLATIONAL MEDICINE, v. 5, n. 8, p. 1048-1057, AUG 2016. Web of Science Citations: 13.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.