Evaluation of protein and energetic metabolism in acute kidney injury patients undergoing different dialysis methods

• Grant number: 12/02404-9
• Support Opportunities: Regular Research Grants
• Start date: June 01, 2012
• End date: May 31, 2014
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: André Luís Balbi
• Grantee: André Luís Balbi
• Host Institution: Faculdade de Medicina (FMB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil

Abstract

Acute kidney injury is associated with high mortality in patients admitted to intensive care units (ICU), with few studies on the protein and energetic metabolism of AKI patients with need of dialysis. The main objective of this study is to evaluate the protein and energetic metabolism by the nitrogen balance and resting energy expenditure, respectively of acute tubular necrosis patients treated with hemodialysis or peritoneal dialysis. Secondary objectives will assess whether the protein and energetic metabolism may be early markers of systemic infectious and evaluate the correlation between protein and energetic hypermetabolism and mortality of these patients. One hundred patients will be studied prospectively, 50 patients treated with at least two sessions of conventional or prolonged hemodialysis and 50 patients treated with at least two sessions of continuous peritoneal dialysis at the Clinical Hospital of Botucatu School of Medicine - UNESP. For each patient will be applied protocol with initial and evolutionary clinical, nutritional and laboratory data from the indication of the dialysis procedure until recovery of renal function or death. Results will be presented using descriptive statistics of the population studied and different statistical tests according to each objective of the study. All results of testing statistical hypotheses will be discussed in level of 5% significance. (AU)