| Grant number: | 11/52090-8 |
| Support Opportunities: | Regular Research Grants |
| Start date: | July 01, 2012 |
| End date: | June 30, 2014 |
| Field of knowledge: | Health Sciences - Medicine - Pathological Anatomy and Clinical Pathology |
| Principal Investigator: | Jorge Esquiche León |
| Grantee: | Jorge Esquiche León |
| Host Institution: | Faculdade de Odontologia de Ribeirão Preto (FORP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil |
| City of the host institution: | Ribeirão Preto |
Abstract
The detection of epithelial dysplasia in oral leukoplakia (OL) and actinic cheilitis (AC) is the most important indicator for risk of squamous cell carcinoma (SCC), Unlike the lower lip SCC (LL-SCC), the oral cavity SCC (OSCC) is characterized by a high degree of local invasion and frequent lymph node metastasis. Despite great advances in the OSCC therapy, the 5-year survival rate has remained at less than 50% for the past 40 years. Several studies nave demonstrated that the immune system cannot only protect the host against tumor development, but also it has the ability to promote tumor growth, a dual effect of the immune system called "câncer imunoediting", in which the enzyme indoleamine 2,3 - dioxygenase (IDO) is directly involved. While these mechanisms in OL and AC are unknown, only two studies evaluating the expression of IDO in OSCC and LL-SCC have shown heterogeneous distribution. Such studies represent an excellent opportunity for a comparative analysis of the immune response in both potentially malignant disorders and SCC, besides to evaluate for effects of solar ultraviolet radiation. The purpose of this research project is to analyze, through an extensive immunohistochemical panel, the location and functional status of dendritic cells, cytotoxic lymphocytes and IDO expression in normal oral mucosa (n= 10), OL (n= 15), AC (n= 15), OSCC (n = 15) and LL-SCC (n = 10). All these cases will be retrieved from the files of the Histopathology Laboratory of the Faculty of Dentistry of Ribeirão Preto, University of São Paulo (FORP-USP). The results will help to better define the subtypes of cell activation and regulation of the immune system and its relationship with IDO expression, in order to contribute to the development of immunotherapeutic strategies for SCC treatment. (AU)
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