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Executive and memory functions of patients with mesial temporal sclerosis: association between neuropsychological evaluation and new neuroimage techniques

Grant number: 12/09025-3
Support type:Regular Research Grants
Duration: August 01, 2012 - January 31, 2015
Field of knowledge:Humanities - Psychology
Principal Investigator:Geraldo Busatto Filho
Grantee:Geraldo Busatto Filho
Home Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Assoc. researchers:Kette Dualibi Ramos Valente ; Patricia Rzezak Tencer

Abstract

Studies of patients with mesial temporal sclerosis have emphasized the episodic memory impairment related to hippocampal damage. There are few studies investigating other types of memory, such as semantic and everyday memory, even though these cognitive functions may also be impaired in these patients. Executive dysfunctions have also been evidenced in these patients, although there is a lack of consensus on the neuroanatomical and neurophysiological causes of these deficits. In addition, many of the current studies used only one test to investigate this complex cognitive function and there was an emphasis on the evaluation of cold executive functions. The objectives of this study are: (i) evaluate the different types of memory and executive functions of patients with mesial temporal sclerosis, (ii) categorize patients according to their level of cognitive impairment, (iii) measure the influence of epilepsy clinical variables and mood disorders in cognitive functioning of patients, (iv) determine the presence of changes in gray and white matter in the whole brain and investigate whether such changes are related to the presence and severity of cognitive deficits and (v) verify if pattern classification methodology can discriminate between different levels of cognitive dysfunction in patients with mesial temporal sclerosis.Forty-six patients with mesial temporal sclerosis will be evaluated, and their performance will be compared to 46 healthy subjects without neurological and psychiatric disorders, matched with patients by sex, age and socio-economic and demographic background. Subjects will undergo neuropsychological evaluation and MRI scan, from which voxel-based morphometry, diffusion tensor imaging and pattern classification will be obtained. (AU)

Scientific publications (8)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
RZEZAK, PATRICIA; MOSCHETTA, SYLVIE PAES; MENDONCA, MELANIE; MAIA NOBRE PAIVA, MARIA LUISA; COAN, ANA CAROLINA; GUERREIRO, CARLOS; RAMOS VALENTE, KETTE DUALIBI. Higher IQ in juvenile myoclonic epilepsy: Dodging cognitive obstacles and ``masking{''} impairments. Epilepsy & Behavior, v. 86, p. 124-130, SEP 2018. Web of Science Citations: 1.
RZEZAK, PATRICIA; GUIMARAES, CATARINA A.; GUERREIRO, MARILISA M.; VALENTE, KETTE D. The impact of intelligence on memory and executive functions of children with temporal lobe epilepsy: Methodological concerns with clinical relevance. EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY, v. 21, n. 3, p. 500-506, MAY 2017. Web of Science Citations: 4.
RZEZAK, PATRICIA; LIMA, ELLEN MARISE; GARGARO, ANA CAROLINA; COIMBRA, ERICA; DE VINCENTIIS, SILVIA; VELASCO, TONICARLO RODRIGUES; LEITE, JOAO PEREIRA; BUSATTO, GERALDO F.; VALENTE, KETTE D. Everyday memory impairment in patients with temporal lobe epilepsy caused by hippocampal sclerosis. Epilepsy & Behavior, v. 69, p. 31-36, APR 2017. Web of Science Citations: 8.
VALENTE, KETTE D.; DE PAOLA, LUCIANO; PALMINI, ANDRE; FAVERET, EDUARDO; DE ARAUJO-FILHO, GERARDO MARIA; VAN DER LINDEN, HELIO; BIANCHIN, MARINO M.; WALZ, ROGER; ALESSI, RUDA; VELASCO, TONICARLO; TEIXEIRA, WAGNER A.; LAFRANCE, JR., W. CURT. The approach to patients with psychogenic nonepileptic seizures in epilepsy surgery centers regarding diagnosis, treatment, and education. Epilepsy & Behavior, v. 68, p. 78-83, MAR 2017. Web of Science Citations: 6.
RZEZAK, PATRICIA; LIMA, ELLEN MARISE; PEREIRA, FABRICIO; GARGARO, ANA CAROLINA; COIMBRA, ERICA; DE VINCENTIIS, SILVIA; VELASCO, TONICARLO RODRIGUES; LEITE, JOAO PEREIRA; BUSATTO, GERALDO F.; VALENTE, KETTE D. Decision-making in patients with temporal lobe epilepsy: Delay gratification ability is not impaired in patients with hippocampal sclerosis. Epilepsy & Behavior, v. 60, p. 158-164, JUL 2016. Web of Science Citations: 4.
RZEZAK, PATRICIA; MOSCHETTA, SYLVIE P.; LIMA, ELLEN; CASTRO, CAROLINA X. L.; VINCENTIIS, SILVIA; COAN, ANA CAROLINA; GUERREIRO, CARLOS; BUSATTO FILHO, GERALDO; VALENTE, KETTE D. Distinct domains of impulsivity are impaired in juvenile myoclonic epilepsy but not in temporal lobe epilepsy. Epilepsy & Behavior, v. 45, p. 44-48, APR 2015. Web of Science Citations: 3.
VALENTE, KETTE D.; RZEZAK, PATRICIA; LAFRANCE, JR., W. CURT. Standard medical care for psychogenic nonepileptic seizures in Brazil. Epilepsy & Behavior, v. 45, p. 128-135, APR 2015. Web of Science Citations: 6.
RZEZAK, PATRICIA; VALENTE, KETTE D.; DUCHOWNY, MICHAEL S. Temporal lobe epilepsy in children: Executive and mnestic impairments. Epilepsy & Behavior, v. 31, p. 117-122, FEB 2014. Web of Science Citations: 16.

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