Neuropsychological assessment of children and adolescents with OCD: comparison with healthy controls and impact of treatment

• Grant number: 16/04595-7
• Support Opportunities: Scholarships in Brazil - Master
• Effective date (Start): July 01, 2016
• Effective date (End): March 31, 2018
• Field of knowledge: Health Sciences - Medicine - Psychiatry
• Principal Investigator: Roseli Gedanke Shavitt
• Grantee: Marina de Marco e Souza
• Host Institution: Instituto de Psiquiatria Doutor Antonio Carlos Pacheco e Silva (IPq). Hospital das Clínicas da Faculdade de Medicina da USP (HCFMUSP). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil

Abstract

Introduction: The literature on neuropsychological profile of children and adolescents with obsessive-compulsive disorder (OCD) is still quite scarce and inconsistent when it comes to data on the possible cognitive impairment in this population. The aforementioned deterioration relates to fronto-striatal circuitry, especially with regard to executive functions and nonverbal memory. Objectives: To assess possible changes in cognitive functioning of children and adolescents with OCD and associations between neuropsychological measures, clinical data and response to pharmacological and psychotherapeutic treatments. Methods: 86 patients with OCD and 86 healthy controls, aged between 6 and 17 years, will be evaluated by scales and questionnaires to assess psychiatric symptoms and by a battery of neuropsychological tests. All subjects will undergo such assessments at an early time, while patients after being randomized between two possibilities of treatment, cognitive-behavioral group therapy or fluoxetine, will undergo two new assessments: at the 14th and then at the 28th weeks of treatment. Assumptions: 1) patients will present impairments in tasks that assess planning, mental flexibility, inhibitory control and non-verbal episodic memory when compared with healthy controls; 2) the treatments will have a positive influence in the improvement of cognitive functions of patients, especially those that are compromised compared to controls; 3) clinical improvement will correlate positively with improved neuropsychological performance of patients. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

BERNARDES, ELISA TEIXEIRA; SARAIVA, LEONARDO CARDOSO; DE MARCO E SOUZA, MARINA; QUEIROZ-HOEXTER, MARCELO; CHACON, PRISCILA; REQUENA, GUARACI; MIGUEL, EURIPEDES CONSTANTINO; SHAVITT, ROSELI GEDANKE; POLANCZYK, GUILHERME VANONI; CAPPI, CAROLINA; et al. Cognitive performance in children and adolescents at high-risk for obsessive-compulsive disorder. BMC Psychiatry, v. 20, n. 1, JUL 20 2020. (16/05865-8, 16/04595-7)

BATISTUZZO, MARCELO CAMARGO; DE MARCO E SOUZA, MARINA; BERNARDES, ELISA TEIXEIRA; REQUENA, GUARACI; MIGUEL, EURIPEDES CONSTANTINO; SHAVITT, ROSELI GEDANKE. Intelligence quotient (IQ) in pediatric patients with obsessive-compulsive disorder. JOURNAL OF OBSESSIVE-COMPULSIVE AND RELATED DISORDERS, v. 26, p. 6-pg., 2020-07-01. (08/57896-8, 16/04595-7, 16/05865-8)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

SOUZA, Marina de Marco e. Neuropsychological evaluation of children and adolescents with OCD: comparison with healthy controls and post-treatment outcomes. 2018. Master's Dissertation - Universidade de São Paulo (USP). Faculdade de Medicina (FM/SBD) São Paulo.