Innate immunity in the elderly: predisposing factors for sepsis and other complex diseases

• Grant number: 12/03677-9
• Support Opportunities: Regular Research Grants
• Start date: August 01, 2012
• End date: July 31, 2014
• Field of knowledge: Biological Sciences - Immunology - Applied Immunology
• Principal Investigator: Marcel Cerqueira Cesar Machado
• Grantee: Marcel Cerqueira Cesar Machado
• Host Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated researchers: Denise Frediani Barbeiro ; Eduardo Moraes Rego Reis ; Fabiano Pinheiro da Silva ; Hermes Vieira Barbeiro

Abstract

This project aims to search for new biomarkers in the elderly. We use blood collected from young and elderly volunteers of the Hospital das Clinicas, Faculty of Medicine, University of Sao Paulo. This study aims to clarify how the elderly patient ages and characteristics of innate immunity in the process of senescence and as a predisposing factor for development of sepsis and other complex diseases, since age-related diseases are the leading cause of death worldwide. We intend, therefore, carry out extensive gene expression analysis, in order to identify markers of senescence and molecules with critical role in the process of aging and illness in this population. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

DA SILVA PELLEGRINA, DIOGO VIEIRA; SEVERINO, PATRICIA; BARBEIRO, HERMES VIEIRA; ANDREGHETTO, FLAVIA MAZIERO; VELASCO, IRINEU TADEU; DE SOUZA, HERALDO POSSOLO; CESAR MACHADO, MARCEL CERQUEIRA; REIS, EDUARDO MORAES; DA SILVA, FABIANO PINHEIRO. Septic Shock in Advanced Age: Transcriptome Analysis Reveals Altered Molecular Signatures in Neutrophil Granulocytes. PLoS One, v. 10, n. 6, JUN 5 2015. (12/03677-9, 14/03150-6)