Ultrathin films to fabrication of biosensors and biomembrane mimicking: applications in environmental and health areas

• Grant number: 08/10851-0
• Support Opportunities: Research Grants - Young Investigators Grants
• Start date: April 01, 2009
• End date: March 31, 2013
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Physical-Chemistry
• Principal Investigator: Luciano Caseli
• Grantee: Luciano Caseli
• Host Institution: Instituto de Ciências Ambientais, Químicas e Farmacêuticas (ICAQF). Universidade Federal de São Paulo (UNIFESP). Campus Diadema. Diadema , SP, Brazil
• Associated scholarship(s): 11/14289-7 - Adsorption of pollutants metals and enzymes in hybrid Langmuir-Blodgett films immobilized with algal polysaccharides / phospholipids, BP.MS; 10/08505-6 - Immobilization of conjugated block polymers in Langmuir-Blogett films, BP.IC; 10/07248-0 - Interaction of sulfated polysaccharides with thin films organized at the air-water interface, BP.IC

Abstract

This project aims to the fabrication of three types of ultrathin films organized at the molecular level named layer-by-layer films (LbL), Langmuir monolayers, and Langmuir-Blodgett films (Lb). Several materials will be essayed to be immobilized on the solid matrices (LbL and LB), including synthetic polymers, biopolymers and lipids. In this way, the ultrathin films will be characterized and analyzed aiming their applicability as sensors with environmental, technological or biomedical interest. The use of Langmuir films of lipids and other biological molecules (proteins, drugs, and nucleotides) will serve as models for biointerfaces, such as vesicles and cell membranes. In short, one intends to install in the new campus of Diadema from Federal University of Sao Paulo, a center to fabricate thin films and Surface Chemistry, through the purchase of a Langmuir trough. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

GOTO, THIAGO EICHI; CASELI, LUCIANO. Understanding the Collapse Mechanism in Langmuir Monolayers through Polarization Modulation-Infrared Reflection Absorption Spectroscopy. Langmuir, v. 29, n. 29, p. 9063-9071, JUL 23 2013. (08/10851-0)

GOTO, THIAGO E.; LOPEZ, RICARDO F.; IOST, RODRIGO M.; CRESPILHO, FRANK N.; CASELI, LUCIANO. Monolayer Collapse Regulating Process of Adsorption-Desorption of Palladium Nanoparticles at Fatty Acid Monolayers at the Air-Water Interface. Langmuir, v. 27, n. 6, p. 2667-2675, MAR 15 2011. (08/10851-0, 10/07248-0, 09/15558-1)

CASELI, LUCIANO; TIBURCIO, VERA L. B.; VARGAS, FREY F. R.; MARANGONI, SERGIO; SIQUEIRA, JR., JOSE R.. Enhanced Architecture of Lipid-Carbon Nanotubes as Langmuir-Blodgett Films to Investigate the Enzyme Activity of Phospholipases from Snake Venom. Journal of Physical Chemistry B, v. 116, n. 45, p. 13424-13429, NOV 15 2012. (08/10851-0)