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Interaction of nanoparticles of gold and silver in Langmuir films as membrane models

Grant number: 15/09586-3
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): August 01, 2015
Effective date (End): December 31, 2017
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Physical-Chemistry
Principal Investigator:Luciano Caseli
Grantee:Rafael Leonardo Cruz Gomes da Silva
Host Institution: Instituto de Ciências Ambientais, Químicas e Farmacêuticas (ICAQF). Universidade Federal de São Paulo (UNIFESP). Campus Diadema. Diadema , SP, Brazil


The project aims to study the interaction of gold nanoparticles and silver stabilized polivinilfenol (PVP) in Langmuir monolayers of lipids formed in the air-water interface, combining tensiometric, spectroscopic and imaging techniques. As such nanoparticles have potential action as bactericides and fungicides, acting, so in micro-organism membranes, this work involves the use of Langmuir films as models for biomembranes. Nanoparticles are inserted in the form of aqueous subphase to dipalmitoifosfatidilcolina monolayers of phospholipids (DPPC) and dipalmitoyl phosphatidyl glycerol (DPPG) and the effect will be evaluated by means of isotherms of surface-area pressure-area, surface potential, Brewster angle microscopy (BAM) and infrared spectroscopy (PM-IRRAS).

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
CRUZ GOMES DA SILVA, RAFAEL LEONARDO; OLIVEIRA DA SILVA, HELOIZA FERNANDA; DA SILVA GASPAROTTO, LUIZ HENRIQUE; CASELI, LUCIANO. How the interaction of PVP-stabilized Ag nanoparticles with models of cellular membranes at the air-water interface is modulated by the monolayer composition. Journal of Colloid and Interface Science, v. 512, p. 792-800, . (15/09586-3)

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