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Study of the Interaction of Nanoparticles and Nanotubes with Cell Membrane Models and Possible Applications

Grant number: 10/00486-2
Support Opportunities:Scholarships in Brazil - Doctorate
Effective date (Start): October 01, 2010
Effective date (End): September 30, 2014
Field of knowledge:Physical Sciences and Mathematics - Physics - Condensed Matter Physics
Principal Investigator:Valtencir Zucolotto
Grantee:Thiers Massami Uehara
Host Institution: Instituto de Física de São Carlos (IFSC). Universidade de São Paulo (USP). São Carlos , SP, Brazil
Associated scholarship(s):12/06394-8 - Study of interaction of magnetic nanoparticles with cancer cells for application in nanomedicine, BE.EP.DR


The development of nanoscience and nanotechnology in recent years has promoted a new frontier in the study of matter, allowing known compounds have rediscovered their properties to be manipulated at the molecular level. Therefore, there are materials that have been having a high significance, for example, carbon nanotubes (CNTs) and metal nanoparticles, because they are endowed with mechanical properties, thermal and power that make them suitable for the development and application devices, especially in the biotechnology and sensors. Several areas benefit from the use of this technology, for example, food, medical, cosmetic, industrial, among others. One possible approach to use these composites is in the manufacture of new intelligent materials for biotechnological applications. Because of this great potential use of nanocomposites in biological systems, it is very interesting to investigate how these materials interact at the molecular level models of cell membranes, or with living systems, with a view to possible nanotoxicidade. This project provides for the study of thin films involving the interaction of carbon nanotubes and metal nanoparticles with model membranes and cell membranes. These thin films are manufactured using the techniques of Langmuir films and Langmuir-Blodgett, allowing also occur in conjunction with other molecules of interest, and thus aiming at possible application in sensors. These nanocomposites will first be evaluated by conventional techniques for characterization of thin films, spectroscopy in the infrared and Raman. Is also used the technique of vibrational spectroscopy for Generation Sum Frequency (SFG). SFG spectroscopy is inherently sensitive to interfaces. In addition to spectral information, which is usually related to the structure of the surface, the technique provides information about the orientation of molecules in the interface. Later, will assess the potential application of these nanomaterials in conjunction with lipids and other molecules such as phthalocyanines for application in biosensors.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
UEHARA, THIERS MASSAMI; CANCINO-BERNARDI, JULIANA; MIRANDA, PAULO BARBEITAS; ZUCOLOTTO, VALTENCIR. Investigating the interactions of corona-free SWCNTs and cell membrane models using sum-frequency generation. SOFT MATTER, v. 16, n. 24, p. 5711-5717, . (12/03570-0, 18/02819-0, 10/00486-2)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
UEHARA, Thiers Massami. Interaction of nanomaterials with cell membrane models and with stem cells. 2014. Doctoral Thesis - Universidade de São Paulo (USP). Escola de Engenharia de São Carlos (EESC/SBD) São Carlos.

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