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Expression of osteopontin in cocultures of osteoblastic cells and squamous cell carcinoma cells and its effects on the neoplastic cell phenotype and osteoclastic activation

Abstract

Squamous cell carcinoma (SCC) is the most prevalent malignant neoplasm of the oral structures, which may invade and destroy bone tissue due to increased osteoclastic activity. The matricelular protein osteopontin (OPN) has been associated with more aggressive tumors, since OPN can promote cell adhesion, proliferation and invasion. In bone, OPN is the most abundant non-collagenous protein, especially concentrated at bone interfaces (cement lines and the lamina limitantes), and play important roles in osteoblast and osteoclast adhesion and function. The present study aims to evaluate the expression of OPN in cocultures of osteoblastic cells and oral SCC and its effects on the neoplastic phenotype and osteoclastic activation. It will be evaluated: 1) OPN expression profile of in cocultures of osteoblastic cells and oral SCC; 2) osteoblastic cell-derived OPN effects on oral SCC genotype and phenotype and 3) the effects of the secreted OPN from cocultures on osteoclastic activation. (AU)

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
TEIXEIRA, LUCAS NOVAES; SPINOLA DE CASTRO RAUCCI, LARISSA MOREIRA; ALONSO, GABRIELA CAROLINE; DELLA COLETTA, RICARDO; ROSA, ADALBERTO LUIZ; DE OLIVEIRA, PAULO TAMBASCO. Osteopontin expression in co-cultures of human squamous cell carcinoma-derived cells and osteoblastic cells and its effects on the neoplastic cell phenotype and osteoclastic activation. TUMOR BIOLOGY, v. 37, n. 9, p. 12371-12385, SEP 2016. Web of Science Citations: 3.

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