The influence of intermuscular fat and body composition in postural control in pat...
| Grant number: | 12/07809-7 |
| Support type: | Regular Research Grants |
| Duration: | October 01, 2012 - September 30, 2014 |
| Field of knowledge: | Health Sciences - Nutrition - Nutritional Analysis of Population |
| Principal Investigator: | Patricia Helen de Carvalho Rondó |
| Grantee: | Patricia Helen de Carvalho Rondó |
| Home Institution: | Faculdade de Saúde Pública (FSP). Universidade de São Paulo (USP). São Paulo , SP, Brazil |
| Assoc. researchers: | Liania Alves Luzia |
Abstract
Obesity is an epidemic disease with high prevalence since the early years of life. It is considered as a major public health problem. Characterized by excess of adipose tissue (AT), the obesity installed during human development can lead to long-term effects on physiology, such as the developing of chronic diseases. The AT has an important endocrine function and is capable of releasing signaling and mediators proteins called cytokines, conditioning their communication with various tissues. The expansion of AT in obesity leads to an inflammatory process and alters the secretion of certain cytokines. In obese subjects, the cytokine zinc-±2-glycoprotein (ZAG) and adiponectin expression is decreased. The ZAG has been characterized as a modulator of the AT, due to its lipolytic action in adipocytes while adiponectin has an anti-inflammatory role. Leptin and tumor necrosis factor-alpha (TNF-±) are increased in obesity and have a pro-inflammatory role. TNF-± is an important factor regulating the expression of ZAG and adiponectin. Due to the relevance of the AT in the progression of metabolic disorders it is necessary to monitor the development of body composition since the beginning of life, in order to find endocrine important changes in the genesis of obesity. Thus, the aim of this cohort study is to measure the concentrations of ZAG, adiponectin, leptin and TNF-± in the umbilical cord blood and correlate with body composition in 200 infants in the first 6 months of life. Body composition will be performed by the method of plethysmography. Cytokines will be determined in umbilical cord blood by the ELISA method. Multiple linear regression analysis will determine the relationship between cytokines and body composition monthly from birth to 6 months of age. (AU)