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The relationship between zinc alpha2-glicoprotein, adiponectin, leptin and tumor necrosis factor-alpha in umbilical cord blood and body composition of infants from birth to 6 months of age

Grant number: 12/07809-7
Support type:Regular Research Grants
Duration: October 01, 2012 - September 30, 2014
Field of knowledge:Health Sciences - Nutrition - Nutritional Analysis of Population
Principal researcher:Patricia Helen de Carvalho Rondó
Grantee:Patricia Helen de Carvalho Rondó
Home Institution: Faculdade de Saúde Pública (FSP). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Assoc. researchers:Liania Alves Luzia


Obesity is an epidemic disease with high prevalence since the early years of life. It is considered as a major public health problem. Characterized by excess of adipose tissue (AT), the obesity installed during human development can lead to long-term effects on physiology, such as the developing of chronic diseases. The AT has an important endocrine function and is capable of releasing signaling and mediators proteins called cytokines, conditioning their communication with various tissues. The expansion of AT in obesity leads to an inflammatory process and alters the secretion of certain cytokines. In obese subjects, the cytokine zinc-±2-glycoprotein (ZAG) and adiponectin expression is decreased. The ZAG has been characterized as a modulator of the AT, due to its lipolytic action in adipocytes while adiponectin has an anti-inflammatory role. Leptin and tumor necrosis factor-alpha (TNF-±) are increased in obesity and have a pro-inflammatory role. TNF-± is an important factor regulating the expression of ZAG and adiponectin. Due to the relevance of the AT in the progression of metabolic disorders it is necessary to monitor the development of body composition since the beginning of life, in order to find endocrine important changes in the genesis of obesity. Thus, the aim of this cohort study is to measure the concentrations of ZAG, adiponectin, leptin and TNF-± in the umbilical cord blood and correlate with body composition in 200 infants in the first 6 months of life. Body composition will be performed by the method of plethysmography. Cytokines will be determined in umbilical cord blood by the ELISA method. Multiple linear regression analysis will determine the relationship between cytokines and body composition monthly from birth to 6 months of age. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
EUCLYDES, VERONICA L. V.; CASTRO, NATALIA P.; LIMA, LOURDES R.; BRITO, CYRO; RIBEIRO, LAISA; SIMOES, FERNANDA AGAPITO; REQUENA, GUARACI; LUZIA, LIANIA ALVES; RONDO, PATRICIA HELEN. Cord blood concentrations of leptin, zinc-alpha 2-glycoprotein, and adiponectin, and adiposity gain during the first 3 mo of life. NUTRITION, v. 54, p. 89-93, . (12/07809-7)

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