Biocompatibility and bone repair: in vitro and in vivo studies testing a new flexible biomaterial

• Grant number: 12/13422-8
• Support Opportunities: Regular Research Grants
• Start date: December 01, 2012
• End date: November 30, 2014
• Field of knowledge: Interdisciplinary Subjects
• Principal Investigator: Ana Claudia Muniz Renno
• Grantee: Ana Claudia Muniz Renno
• Host Institution: Centro de Ciências Biológicas e da Saúde (CCBS). Universidade Federal de São Carlos (UFSCAR). São Carlos , SP, Brazil
• Associated researchers: Nivaldo Antonio Parizotto ; Paulo Sérgio Bossini

Abstract

The bone healing is regenerative process that includes the highly complex interaction of a series of biological events, crucial for the restoration of the integrity of bone tissue. During this process, there may be changes that culminate in the regeneration deficiency and therefore the delay of the consolidation or non-union bone. In such cases, there is a need for bone-replacement implants for the favoring bone regeneration. A novel biomaterial manufactured from Bioglass has been proven to be viable biomaterials for use as bone implants because they have an appropriate structure for tissue growth and possible osteogenic potential. However, it is not know what their real influence in the mechanisms of action and the biological interactions that underlie the process of bone repair. Within this context, this study aims to evaluate the biocompatibility and biological response of this material. For this purpose, in vitro and in vivo tests (in a model of tibial bone defects in rats) will be performed. (AU)