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Study of the biocompatibility and bone repair: in vitro and in vivo test using

Grant number: 12/13477-7
Support type:Regular Research Grants
Duration: March 01, 2013 - February 28, 2015
Field of knowledge:Interdisciplinary Subjects
Principal Investigator:Ana Claudia Muniz Renno
Grantee:Ana Claudia Muniz Renno
Home Institution: Instituto de Saúde e Sociedade (ISS). Universidade Federal de São Paulo (UNIFESP). Campus Baixada Santista. Santos , SP, Brazil
Assoc. researchers:Edgar Dutra Zanotto ; Nivaldo Antonio Parizotto ; Oscar Peitl Filho ; Paulo Sérgio Bossini


The bone healing is regenerative process that includes the highly complex interaction of a series of biological events, crucial for the restoration of the integrity of bone tissue. During this process, there may be changes that culminate in the regeneration deficiency and therefore the delay of the consolidation or non-union bone. In such cases, there is a need for bone-replacement implants for the favoring bone regeneration. The Biosilicate® scaffolds have proven to be viable biomaterials for use as bone implants because they have an appropriate structure for tissue growth and have a great osteogenic potential. However, it is not know what their real influence in the mechanisms of action and the biological interactions that underlie the process of bone repair. In this sense, molecular evidence would be of great value to an accurate understanding of this biological scenario, since the cellular and molecular changes induced by biomaterial manage bone formation. Within this context, this study aims to evaluate the action of the Biosilicate® scaffolds in the process of consolidation of tibial bone defects in rats by histological analyzes of bone defect, analysis of gene expression related to bone regeneration and analysis of the levels of mediators during the inflammatory of the mechanisms analysis of inflammatory mediators during tissue repair. These information enables a more precise understanding of the mechanisms by which these biomaterials interacts with the biological system during the process of bone repair, which can contribute to the development of further studies with the biomaterial in order to develop an effective and reliable treatment for fracture healing. (AU)