Gelatin particle systems containing flavonoid: development, characterization and application in sunscreen formulations

• Grant number: 12/04435-9
• Support Opportunities: Regular Research Grants
• Duration: December 01, 2012 - February 28, 2015
• Field of knowledge: Health Sciences - Pharmacy - Pharmaceutical Technology
• Principal Investigator: André Rolim Baby
• Grantee: André Rolim Baby
• Host Institution: Faculdade de Ciências Farmacêuticas (FCF). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

Sunscreens are used to prevent effects of ultraviolet radiation such as burns, photoaging, carcinoma, melanoma and induction of systemic immunosuppression. Currently it has become trend in the cosmetic market, the decrease in concentration of chemical filters in sunscreen formulations. This fact is explained by the emergence of adverse reactions caused by topical formulations containing such components. Natural products are important sources of bioactive molecules. For these reasons, this project aims to obtain microparticles or nanoparticles of gelatin containing rutin and/or quercetin perform the physical, physico-chemical and functional caracterization and develop bioactive sunscreens with gelatin particles containing flavonoid. The gelatin systems containing flavonoid will be obtained by desolvation technique in two steps. The characterization of the particles will be carried out through the following analysis: distribution of particle size, zeta potential, rate of association and antiradical activity. The formulations will be evaluated in relation to the organoleptic characteristics, the pH value, the apparent viscosity and the photoprotection efficacy obtained in vitro. The results will present perspectives of application in the strategic areas of photoprotection (AU)

Scientific publications

(8)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

DARIO, MICHELLI F.; FREIRE, THAMIRES BATELLO; SALES DE OLIVEIRA PINTO, CLAUDINEIA PARECIDA; AURORA PRADO, MARIA SEGUNDA; BABY, ANDRE R.; VELASCO, MARIA VALERIA R.. Tryptophan and kynurenine determination in human hair by liquid chromatography. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, v. 1065, p. 59-62, OCT 15 2017. (12/04435-9, 13/16070-8, 13/16265-3)

GRAZIOLA, FABIANA; CANDIDO, THALITA MARCILIO; DE OLIVEIRA, CAMILA AREIAS; PERES, DANIELA D'ALMEIDA; ISSA, MICHELE GEORGES; MOTA, JOANA; ROSADO, CATARINA; CONSIGLIERI, VLADI OLGA; KANEKO, TELMA MARY; ROBLES VELASCO, MARIA VALERIA; et al. Gelatin-based microspheres crosslinked with glutaraldehyde and rutin oriented to cosmetics. Brazilian Journal of Pharmaceutical Sciences, v. 52, n. 4, p. 603-612, OCT-DEC 2016. (12/04435-9, 12/19972-0)

PERES, DANIELA D'ALMEIDA; ARIEDE, MAIRA BUENO; CANDIDO, THALITA MARCILIO; DE ALMEIDA, TANIA SANTOS; LOURENCO, FELIPE REBELLO; CONSIGLIERI, VLADI OLGA; KANEKO, TELMA MARY; ROBLES VELASCO, MARIA VALERIA; BABY, ANDRE ROLIM. Quality by design (QbD), Process Analytical Technology (PAT), and design of experiment applied to the development of multifunctional sunscreens. DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, v. 43, n. 2, p. 246-256, 2017. (12/04435-9)

DE OLIVEIRA, CAMILA AREIAS; PERES, DANIELA D'ALMEIDA; GRAZIOLA, FABIANA; BOU CHACRA, NADIA ARACI; BARROS DE ARAUJO, GABRIEL LIMA; FLORIDO, ANA CATARINA; MOTA, JOANA; ROSADO, CATARINA; ROBLES VELASCO, MARIA VALERIA; RODRIGUES, LUIS MONTEIRO; et al. Cutaneous biocompatible rutin-loaded gelatin-based nanoparticles increase the SPF of the association of UVA and UVB filters. European Journal of Pharmaceutical Sciences, v. 81, p. 1-9, JAN 1 2016. (14/05906-0, 12/19972-0, 12/04435-9)

DE OLIVEIRA, CAMILA AREIAS; DARIO, MICHELLI FERRERA; SARRUF, FERNANDA DAUD; AFONSO MARIZ, INES FATIMA; ROBLES VELASCO, MARIA VALERIA; ROSADO, CATARINA; BABY, ANDRE ROLIM. Safety and efficacy evaluation of gelatin-based nanoparticles associated with UV filters. COLLOIDS AND SURFACES B-BIOINTERFACES, v. 140, p. 531-537, APR 1 2016. (14/05906-0, 12/19972-0, 12/04435-9)

NICOLAI, MARISA; MOTA, JOANA; FERNANDES, ANA S.; PEREIRA, FILIPE; PEREIRA, PAULA; REIS, CATARINA P.; ROBLES VELASCO, MARIA VALERIA; BABY, ANDRE ROLIM; ROSADO, CATARINA; RIJO, PATRICIA. Assessment of the Potential Skin Application of Plectranthus ecklonii Benth.. PHARMACEUTICALS, v. 13, n. 6, JUN 2020. (12/04435-9)

ROSADO, CATARINA; TOKUNAGA, VIVIANE KAORI; SAUCE, RAFAEL; DE OLIVEIRA, CAMILA AREIAS; SARRUF, FERNANDA DAUD; PARISE-FILHO, ROBERTO; MAURICIO, ELISABETE; DE ALMEIDA, TENIA SANTOS; ROBLES VELASCO, MARIA VALERIA; BABY, ANDRE ROLIM. Another Reason for Using Caffeine in Dermocosmetics: Sunscreen Adjuvant. FRONTIERS IN PHYSIOLOGY, v. 10, MAY 3 2019. (12/04435-9, 13/08535-0, 13/18689-5)

CANDIDO, THALITA MARCILIO; DE OLIVEIRA, CAMILA AREIAS; ARIEDE, MAIRA BUENO; ROBLES VELASCO, MARIA VALERIA; ROSADO, CATARINA; BABY, ANDRE ROLIM. Safety and Antioxidant Efficacy Profiles of Rutin-Loaded Ethosomes for Topical Application. AAPS PHARMSCITECH, v. 19, n. 4, p. 1773-1780, MAY 2018. (12/04435-9)