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Technological development, safety assessment and clinical effectiveness of rutin-loaded gelatin micro/nanoparticles

Grant number: 12/19972-0
Support Opportunities:Scholarships in Brazil - Doctorate (Direct)
Effective date (Start): May 01, 2013
Effective date (End): December 31, 2015
Field of knowledge:Health Sciences - Pharmacy
Principal Investigator:André Rolim Baby
Grantee:Camila Areias de Oliveira
Host Institution: Faculdade de Ciências Farmacêuticas (FCF). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated scholarship(s):14/05906-0 - Safety and clinical efficacy of rutin-entrapped gelatin nanoparticles, BE.EP.DD


The decrease in chemical filter concentration in sunscreens formulations became a trend in the cosmetic market. This fact is explained by the occurrence of adverse reactions caused by topical formulations containing such components. Vegetable products are important sources of bioactive molecules. For these reasons, this project aims to (1) obtain and rutin-entrapped gelatin particles, (2) perform the physical, physic-chemical, chemical and functional analysis, (3) evaluate the cytotoxicity in vitro , develop bioactive sunscreens with in vitro and in vivo photoprotective efficacy estimated , containing protein based particle. The particles will be obtained by desolvation in two steps. The characterization of the particles will be carried through the following analysis: Determination of pH, particle size distribution, entrapment efficiency, extent of crosslinking and antioxidant activity. The safety of the particles will be evaluated by in vitro cytotoxicity. The formulations will be evaluated in relation to the organoleptic characteristics, the pH value, the apparent viscosity and in vitro photoprotective efficacy estimated by diffuse reflectance spectrophotometry with integrating sphere and in vivo by internationally recognized methodology. The results will present perspectives for the development of an innovative photoprotective and antioxidant ingredient. (AU)

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Scientific publications (4)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
PERES, DANIELA D'ALMEIDA; HUBNER, ALEXANDRA; DE OLIVEIRA, CAMILA AREIAS; DE ALMEIDA, TANIA SANTOS; KANEKO, TELMA MARY; CONSIGLIERI, VLADI OLGA; SALES DE OLIVEIRA PINTO, CLAUDINEIA APARECIDA; ROBLES VELASCO, MARIA VALERIA; BABY, ANDRE ROLIM. Hydrolyzed collagen interferes with in vitro photoprotective effectiveness of sunscreens. Brazilian Journal of Pharmaceutical Sciences, v. 53, n. 2, . (12/19972-0, 10/10739-5)
DE OLIVEIRA, CAMILA AREIAS; PERES, DANIELA D'ALMEIDA; GRAZIOLA, FABIANA; BOU CHACRA, NADIA ARACI; BARROS DE ARAUJO, GABRIEL LIMA; FLORIDO, ANA CATARINA; MOTA, JOANA; ROSADO, CATARINA; ROBLES VELASCO, MARIA VALERIA; RODRIGUES, LUIS MONTEIRO; et al. Cutaneous biocompatible rutin-loaded gelatin-based nanoparticles increase the SPF of the association of UVA and UVB filters. European Journal of Pharmaceutical Sciences, v. 81, p. 1-9, . (14/05906-0, 12/19972-0, 12/04435-9)
GRAZIOLA, FABIANA; CANDIDO, THALITA MARCILIO; DE OLIVEIRA, CAMILA AREIAS; PERES, DANIELA D'ALMEIDA; ISSA, MICHELE GEORGES; MOTA, JOANA; ROSADO, CATARINA; CONSIGLIERI, VLADI OLGA; KANEKO, TELMA MARY; ROBLES VELASCO, MARIA VALERIA; et al. Gelatin-based microspheres crosslinked with glutaraldehyde and rutin oriented to cosmetics. Brazilian Journal of Pharmaceutical Sciences, v. 52, n. 4, p. 603-612, . (12/04435-9, 12/19972-0)
DE OLIVEIRA, CAMILA AREIAS; DARIO, MICHELLI FERRERA; SARRUF, FERNANDA DAUD; AFONSO MARIZ, INES FATIMA; ROBLES VELASCO, MARIA VALERIA; ROSADO, CATARINA; BABY, ANDRE ROLIM. Safety and efficacy evaluation of gelatin-based nanoparticles associated with UV filters. COLLOIDS AND SURFACES B-BIOINTERFACES, v. 140, p. 531-537, . (14/05906-0, 12/19972-0, 12/04435-9)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
OLIVEIRA, Camila Areias de. Desenvolvimento, avaliação da segurança e eficácia clínica de sistemas nanoparticulados de gelatina contendo rutina.. 2015. Doctoral Thesis - Universidade de São Paulo (USP). Conjunto das Químicas (IQ e FCF) (CQ/DBDCQ) São Paulo.

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