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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Cutaneous biocompatible rutin-loaded gelatin-based nanoparticles increase the SPF of the association of UVA and UVB filters

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de Oliveira, Camila Areias [1] ; Peres, Daniela D'Almeida [1] ; Graziola, Fabiana [1] ; Bou Chacra, Nadia Araci [1] ; Barros de Araujo, Gabriel Lima [1] ; Florido, Ana Catarina [2] ; Mota, Joana [2] ; Rosado, Catarina [2] ; Robles Velasco, Maria Valeria [1] ; Rodrigues, Luis Monteiro [2] ; Fernandes, Ana Sofia [2] ; Baby, Andre Rolim [1]
Total Authors: 12
[1] Univ Sao Paulo, Sch Pharmaceut Sci, Dept Pharm, Lab Cosmetol, BR-05508900 Sao Paulo, SP - Brazil
[2] Univ Lusofona, Res Ctr Biosci & Hlth Technol, CBIOS, Lisbon - Portugal
Total Affiliations: 2
Document type: Journal article
Source: European Journal of Pharmaceutical Sciences; v. 81, p. 1-9, JAN 1 2016.
Web of Science Citations: 33

The encapsulation of natural ingredients, such as rutin, can offer improvements in sun protection effectiveness. This strategy can provide enhanced flavonoid content and produces an improved bioactive compound with new physical and functional characteristics. As an alternative to common synthetic-based sunscreens, rutin-entrapped gelatin nanoparticles (GNPs) were designed and associated with ethylhexyl dimethyl PABA (EHDP), ethylhexyl methoxycinnamate (EHMC) and methoxydibenzoylmethane (BMDBM) in sunscreen formulations. The purpose of this study was to develop rutin-loaded gelatin nanoparticles and characterize their physicochemical, thermal, functional and safety properties. Rutin-loaded gelatin nanoparticles increased antioxidant activity by 74% relative to free-rutin (FR) solution. Also, this new ingredient upgraded the Sun Protection Factor (SPF) by 48%, indicating its potential as a raw material for bioactive sunscreens. The safety profile indicated that GNPs and glutaraldehyde (GTA) decreased HaCaT cell viability in a concentration/time-dependent manner. However, both blank nanoparticles (B-NC) and rutin-loaded nanoparticles (R-NC) had good performance on skin compatibility tests. These results functionally characterized rutin-loaded nanoparticles as a safe SPF enhancer in sunscreens, especially in association with UV filters. (C) 2015 Elsevier B.V. All rights reserved. (AU)

FAPESP's process: 14/05906-0 - Safety and clinical efficacy of rutin-entrapped gelatin nanoparticles
Grantee:Camila Areias de Oliveira
Support Opportunities: Scholarships abroad - Research Internship - Doctorate (Direct)
FAPESP's process: 12/19972-0 - Technological development, safety assessment and clinical effectiveness of rutin-loaded gelatin micro/nanoparticles
Grantee:Camila Areias de Oliveira
Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
FAPESP's process: 12/04435-9 - Gelatin particle systems containing flavonoid: development, characterization and application in sunscreen formulations
Grantee:André Rolim Baby
Support Opportunities: Regular Research Grants