| Grant number: | 12/13452-4 |
| Support Opportunities: | Regular Research Grants |
| Start date: | December 01, 2012 |
| End date: | November 30, 2014 |
| Field of knowledge: | Biological Sciences - Microbiology - Applied Microbiology |
| Principal Investigator: | Jonas Contiero |
| Grantee: | Jonas Contiero |
| Host Institution: | Instituto de Biociências (IB). Universidade Estadual Paulista (UNESP). Campus de Rio Claro. Rio Claro , SP, Brazil |
| City of the host institution: | Rio Claro |
Abstract
Despite the numerous advantages of biosurfactants, such as low toxicity, biodegradability and high stability, these compounds are not widely used because of the high cost of production. The application of metabolic engineering tools allows the identification of flow deviations in metabolic pathways involved in the synthesis of ramnolipídios, which can be overcome by genetically modified strains, contributing significantly to the increased production of these metabolites. Therefore this study aims to study the carbon flux in metabolic pathways used by Pseudomonas aeruginosa to produce rhamnolipids and from results establish a stoichiometric model for the production as well as propose genetic modifications in order to direct the carbon flow to increase the production of glycolipid produced by this species. It is also proposed to study the relationship of the gene rhlG with the production of rhamnolipids and also assess whether there are differences in the metabolism of hydrophilic and hydrophobic carbon sources by mutants deleted in the gene mentioned above. (AU)
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