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Quantifying metabolic flux rerouting in dependence of rhamnolipid synthesis of Pseudomonas aeruginosa

Grant number: 15/05412-0
Support type:Scholarships abroad - Research Internship - Post-doctor
Effective date (Start): June 01, 2015
Effective date (End): May 31, 2016
Field of knowledge:Biological Sciences - Microbiology - Applied Microbiology
Principal researcher:Jonas Contiero
Grantee:Roberta Barros Lovaglio
Supervisor abroad: Lars M. Blank
Home Institution: Instituto de Biociências (IB). Universidade Estadual Paulista (UNESP). Campus de Rio Claro. Rio Claro , SP, Brazil
Research place: RWTH Aachen University, Germany  
Associated to the scholarship:11/21228-4 - Metabolic Fluxes Assessment in Complex Network of Rhamnolipids Production by Pseudomonas aeruginosa, BP.PD


Despite the numerous advantages of biosurfactants, such as low toxicity, biodegradability and high stability, these compounds are not widely used because of the high cost of production. The application of metabolic engineering tools allows the identification of flow deviations in metabolic pathways involved in the synthesis of rhamnolipid, which can be overcome by genetically modified strains, contributing significantly to the increased production of these metabolites. In this study we will quantify the carbon flux distribution in Pseudomonas aeruginosa in dependence of rhamnolipid synthesis using 13C-carbon metabolic flux analysis. The results will guide genetic modifications with the ultimate aim to direct the carbon flow towards rhamnolipid synthesis. (AU)

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