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Mutants of Pseudomonas aeruginosa affected in the synthesis of polihidroxyalcanoates and its relation with the production of rhamnolipids.

Grant number: 12/21342-4
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): January 01, 2013
Effective date (End): December 31, 2013
Field of knowledge:Biological Sciences - Microbiology - Applied Microbiology
Principal researcher:José Gregório Cabrera Gomez
Grantee:Viviane Carnier Casaroli
Home Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil


This project aims the evaluation of the synthesis metabolism of rhamnolipids and polihidroxyalcanoates in Pseudomonas aeruginosa. Mutants affected in the biosynthesis of polihidroxyalcanoates will be obtained and evaluated in relation to the production of rhamnolipids from different carbon sources. Since rhamnolipids and polihidroxyalcanoates can be produced simultaneously, the metabolism routes must compete for intermediates of the metabolism. Therefore, the obtention of mutants affected in the biosynthesis of polihidroxyalcanoates can lead to a better understanding of the rhamnolipids synthesis process and present a better comprehension of the factors which directly affect the production of rhamnolipids.

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