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Metabolism study of rhamnolipids production in Pseudmonas aeruginosa LBI 2A1 and PAOI strains

Grant number: 15/14424-2
Support type:Regular Research Grants
Duration: May 01, 2017 - October 31, 2019
Field of knowledge:Biological Sciences - Microbiology - Applied Microbiology
Principal Investigator:Jonas Contiero
Grantee:Jonas Contiero
Home Institution: Instituto de Biociências (IB). Universidade Estadual Paulista (UNESP). Campus de Rio Claro. Rio Claro , SP, Brazil
Assoc. researchers:Roberta Barros Lovaglio

Abstract

Rhamnolipids has been studied for more than 60 years, however some factors involved in the biosynthesis of this molecule, have not yet been elucidated. An important point of divergence concerns the synthesis of the hydrophobic portion of this metabolite. This study aims to confirming the hypothesis that the pathway used for synthesis of lipid precursor of the rhamnolipid depends on the polarity of the carbon source used. In addition, it is proposed to evaluate the relationship of the rhlG gene to the production of rhamnolipids by comparing the carbon flux of the wild-type and mutant of Pseudomonas aeruginosa PAOI. (AU)