Clinical and laboratory factors associated with difficult to control severe asthma in children and adolescents

• Grant number: 12/20532-4
• Support Opportunities: Regular Research Grants
• Start date: January 01, 2013
• End date: June 30, 2015
• Field of knowledge: Health Sciences - Medicine - Maternal and Child Health
• Principal Investigator: Joaquim Carlos Rodrigues
• Grantee: Joaquim Carlos Rodrigues
• Host Institution: Instituto da Criança Professor Doutor Pedro de Alcantara (ICR). Hospital das Clínicas da Faculdade de Medicina da USP (HCFMUSP). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil
• Associated researchers: Karina Pierantozzi Vergani ; Miriam Cardoso Neves Eller

Abstract

The purpose of this study is to identify and compare the clinical, laboratory and inflammatory phenotypes associated with severe asthma and severe asthma difficult to control in patients receiving treatment in outpatient pediatric pulmonology at Child's Institute of Clinical Hospital of University of São Paulo (ICr-HCFMUSP), in order to investigate the factors risk not to control severe asthma. Patients with severe asthma have been followed in the outpatient pulmonology IC-HCFMUSP will be judged by history taking and physical examination conducted by the researchers, who will evaluate the inhalation technique and spirometry performed before and after bronchodilator and FeNO measurements. Will be required laboratory tests, esophageal endoscopy, CT scan of the sinuses, chest tomography, prick test and ENT to investigate factors associated with severe asthma, atopy, rinosinusopatia, gastroesophageal reflux, obstruction of upper airway, dysfunction of vocal folds, immunodeficiency relative, deficiency of alpha1-antripsina, allergic bronchopulmonary aspergillosis. It will also be optimized treatment, if necessary, and enhanced adherence to treatment. On the second visit, after one month, the symptoms will be reassessed, inhalation technique and adherence to treatment. On the third visit, after three months, patients will be divided into two groups: controlled severe asthma and severe asthma difficult to control, according to the ATS criteria, and will be conducted smear of induced sputum and bronchoscopy with bronchoalveolar lavage and bronchial biopsy for study of the cell pattern of inflammation. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

ELLER, MIRIAM C. N.; VERGANI, KARINA P.; SARAIVA-ROMANHOLO, BEATRIZ M.; ANTONANGELO, LEILA; LEONE, CLAUDIO; RODRIGUES, JOAQUIM C.. Can inflammatory markers in induced sputum be used to detect phenotypes and endotypes of pediatric severe therapy-resistant asthma?. PEDIATRIC PULMONOLOGY, v. 53, n. 9, p. 1208-1217, SEP 2018. (12/20532-4)