| Grant number: | 12/02500-8 |
| Support Opportunities: | Research Grants - Young Investigators Grants |
| Start date: | February 01, 2013 |
| End date: | January 31, 2018 |
| Field of knowledge: | Interdisciplinary Subjects |
| Principal Investigator: | Rickson Coelho Mesquita |
| Grantee: | Rickson Coelho Mesquita |
| Host Institution: | Instituto de Física Gleb Wataghin (IFGW). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil |
| City of the host institution: | Campinas |
| Associated researchers: | Andréa Alessio Vieira Alves ; Benito Pereira Damasceno ; Fernando Cendes ; Li Li Min ; Roberto José Maria Covolan |
| Associated scholarship(s): | 13/21764-9 - Characterization of neurovascular-metabolic coupling in humans with diffuse optical techniques,
BP.MS 12/25363-6 - Determination of the dynamical properties in turbid media using diffuse correlation spectroscopy: applications to biological tissue, BP.MS |
Abstract
Cerebrovascular disease and neurotrauma are two of the leading causes of death and disability in Brazil and in the world. It has an enormous socioeconomic impact on society, as well as the patient and the patient's family. Although constant microvascular perfusion monitoring is of fundamental importance following cerebral damage, the lack of suitable instrumentation currently limits clinical interventions aiming to optimize cerebral reperfusion. The goal of this project is to build a novel and portable instrument, based on the principles of diffuse optics, that is capable of measuring cerebral perfusion, oxygenation and metabolism in real time, continuously, non-invasively, and at the patient's bedside. Diffuse optics applied to neuroscience is a multidisciplinary and novel research field in Brazil, and the implementation of a pioneering lab such as the one proposed in this project will open up a research area that, in the long term, will improve instrumentation, basic research and clinical applications. Specifically, the implementation of diffuse correlation spectroscopy, a new and innovative technique capable of measuring perfusion continuously and non-invasively, is proposed in this project. We aim to explore the technique's feasibility and high potential for use in the clinic through studies with stroke patients, a disease that affects millions of people and lacks efficient tools to improve patient outcome. In the end, we expect to demonstrate the utility of this promising research to other applications in neurology, such as in patients with traumatic brain injury and carotid stenosis. (AU)
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