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Development of size-tuned polymeric nanoparticles and evaluation of the interaction with biological environments

Abstract

The proposed topic is focused on the use of "Colloids in the Nanomedicine". Initially, it will be explored the manufacturing of macromolecular nanostructures with potential biological applications. Polymeric Nanoparticles will be produces from a library of biodegradable and biocompatible polyesters and copolyesters aiming the optimization of the experimental conditions towards the production of nanoscale structures with potential application in the drug delivery of antitumoral agents via the EPR (Enhanced Permeation and Retention) effect, where dimensions below the cut-off size of ~ 200 nm is a prerequisite. Subsequently, the focus will move to the groundbreaking topic of nanobiointerfaces. The investigations will be devoted to the nature of interaction between nanoscale structures and biological environments, especially on the kinetics and thermodynamics of adsorption of proteins onto the surface of nanoparticle and the resulting protein-nanoparticle complexes. The formation of protein-nanoparticle complexes has critical implications in the biodistribution, biocompatibility and biorecognition of nanostructures by the living matter. The proposed subject will lead to an in-depth understanding on the preparation of nanostructured entities based on polymer and copolymers and it will guide to the development of manpower with multi and interdisciplinary knowledge enable to teach and lead projects in the main area of "Colloids and Interfaces" in Brazil. To the end, they will have a solid scientific knowledge in scattering methods (especially in the light scattering techniques). (AU)

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Scientific publications (6)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
MICHELETTO, YASMINE MIGUEL SERAFINI; DA SILVEIRA, NADYA PESCE; BARBOZA, DOYLE MELLO; DOS SANTOS, MARINALVA CARDOSO; DE LIMA, VANIA RODRIGUES; GIACOMELLI, FERNANDO CARLOS; MARTINEZ, JULIO CESAR VALDIVIA; FRIZON, TIAGO ELIAS ALLIEVI; DAL BO, ALEXANDRE GONCALVES. Investigation of self-association between new glycosurfactant N-acetyl-beta-D-glucosaminyl-PEG-docosanate and soybean phosphatidylcholine into vesicles. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, v. 467, p. 166-172, . (12/14087-8)
DE OLIVEIRA, ANDERSON M.; JAEGER, ELIEZER; JAEGER, ALESSANDRO; STEPANEK, PETR; GIACOMELLI, FERNANDO C.. Physicochemical aspects behind the size of biodegradable polymeric nanoparticles: A step forward. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, v. 436, p. 1092-1102, . (12/14087-8, 12/17841-5)
JAGER, ALESSANDRO; JAGER, ELIEZER; GIACOMELLI, FERNANDO CARLOS; NALLET, FREDERIC; STEINHART, MILOS; PUTAUX, JEAN-LUC; KONEFAL, RAFAL; SPEVACEK, JIRI; ULBRICH, KAREL; STEPANEK, PETR. Structural changes on polymeric nanoparticles induced by hydrophobic drug entrapment. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, v. 538, p. 238-249, . (12/14087-8)
DE CASTRO, CARLOS E.; MATTEI, BRUNO; RISKE, KARIN A.; JAEGER, ELIEZER; JAEGER, ALESSANDRO; STEPANEK, PETR; GIACOMELLI, FERNANDO C.. Understanding the Structural Parameters of Biocompatible Nanoparticles Dictating Protein Fouling. Langmuir, v. 30, n. 32, p. 9770-9779, . (12/14087-8)
ALLIEVI FRIZON, TIAGO ELIAS; SERAFINI MICHELETTO, YASMINE MIGUEL; WESTRUP, JOSE LUIZ; SILVA WAKABAYASHI, PRISCILA SAYOKO; SERAFIM, FRANCIELI ROCHA; DAMIANI, ADRIANI PAGANINI; LONGARETTI, LUIZA MARTINS; DE ANDRADE, VANESSA MORAES; GIACOMELLI, FERNANDO CARLOS; FORT, SEBASTIEN; et al. New glycosylated conjugate copolymer N-acetyl-beta-D-glucosaminyl-pluronic: Synthesis, self-assembly and biological assays. COLLOIDS AND SURFACES B-BIOINTERFACES, v. 133, p. 323-330, . (12/14087-8)
JAEGER, ELIEZER; GIACOMELLI, FERNANDO C.. Soft Matter Assemblies as Nanomedicine Platforms for Cancer Chemotherapy: A Journey from Market Products Towards Novel Approaches. CURRENT TOPICS IN MEDICINAL CHEMISTRY, v. 15, n. 4, p. 328-344, . (12/14087-8)

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