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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Physicochemical aspects behind the size of biodegradable polymeric nanoparticles: A step forward

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Author(s):
de Oliveira, Anderson M. [1] ; Jaeger, Eliezer [2] ; Jaeger, Alessandro [2] ; Stepanek, Petr [2] ; Giacomelli, Fernando C. [1]
Total Authors: 5
Affiliation:
[1] Univ Fed ABC, Ctr Ciencias Nat & Humanas, BR-09210170 Santo Andre - Brazil
[2] Acad Sci Czech Republic, Inst Macromol Chem, CR-16206 Prague 6 - Czech Republic
Total Affiliations: 2
Document type: Journal article
Source: COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS; v. 436, p. 1092-1102, SEP 5 2013.
Web of Science Citations: 26
Abstract

Surfactant-free PLGA polymeric nanoparticles (PNPs) with hydrodynamic radius (R-H) ranging from 25.8 nm to 128.5 nm were successfully obtained through nanoprecipitation by controlling a variety of physicochemical parameters. The size of the generated PLGA PNPs could be controlled by adjusting the polymer concentration, the choice of organic solvent, mixing different organic solvents or by changing temperature and ionic strength. By optimizing such parameters sub-100 nm uniform PNPs can be produced through this methodology including the advantage and ability to scale-up production. The PNPs have shown a size-dependent effect on the organic solvent and polymer concentration. On the other hand, the polymer-solvent interactions seem not to play a substantial role in the final dimension of the polymer colloids. It has been also evidenced that the size of PNPs can be precisely and linearly tuned by using solvent mixtures as organic phase. (C) 2013 Elsevier B.V. All rights reserved. (AU)

FAPESP's process: 12/14087-8 - Development of size-tuned polymeric nanoparticles and evaluation of the interaction with biological environments
Grantee:Fernando Carlos Giacomelli
Support Opportunities: Regular Research Grants
FAPESP's process: 12/17841-5 - SIZE-TUNED POLYMERIC NANOPARTICLES WITH POTENTIAL APPLICATION IN THE CONTROLLED RELEASE OF CHEMOTHERAPEUTIC AGENTS
Grantee:Anderson Marques de Oliveira
Support Opportunities: Scholarships in Brazil - Master