Nitric oxide releasers based on ruthenium carboxylates and their interaction with some relevant biomolecules

• Grant number: 12/23245-6
• Support Opportunities: Regular Research Grants
• Start date: March 01, 2013
• End date: May 31, 2015
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Inorganic Chemistry
• Principal Investigator: Sofia Nikolaou
• Grantee: Sofia Nikolaou
• Host Institution: Faculdade de Ciências Farmacêuticas de Ribeirão Preto (FCFRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
• City of the host institution: Ribeirão Preto

Abstract

This project proposes the synthesis and characterization of trinuclear ruthenium compounds (clusters) of general formula [Ru3O(CH3COO)6(L)2(NO)]PF6 (L = solvent molecules or pyridinic ligands) aiming to develop nitric oxide releasing species, in a controlled fashion, by means of light irradiation or by reductive reactions, in order to amplify the initial knowledgement reported in literature, which is limited to two papers focusing these compounds for biological applications. In this context, analogues with VO instead of NO may be studied in order to compare to the photoinduced liberation of NO and also the carbonyl compounds may present interesting properties from the biological view - point.This proposal will cover an important gap in the actual literature, which is the synthesis of a new and larger series of ruthenium nitrosyls based on the trinuclear clusters in such a way that, in the next two years, the group will have the opportunity to study, understand and report the behavior of the compound as a novel class of NO releasers. Besides that, we intend to expand the focus of the research performed in our group, by means of the investigation of the complexes reactivity towards biomolecules such as aminoacids, endogenous reductants, human serum albumin and ct-DNA. (AU)

Scientific publications

(4)

(The scientific publications listed on this page originate from the Web of Science or SciELO databases. Their authors have cited FAPESP grant or fellowship project numbers awarded to Principal Investigators or Fellowship Recipients, whether or not they are among the authors. This information is collected automatically and retrieved directly from those bibliometric databases.)

CACITA, NATACHA; NIKOLAOU, SOFIA. Studying the interaction between trinuclear ruthenium complexes and human serum albumin by means of fluorescence quenching. Journal of Luminescence, v. 169, n. A, p. 115-120, JAN 2016. (12/23245-6)

SEUANES, GABRIELA CAMPOS; MOREIRA, MARIETE BARBOSA; PETTA, TANIA; FREIRE DE MORAES DEL LAMA, MARIA PERPETUA; BERALDO DE MORAES, LUIZ ALBERTO; MORAES DE OLIVEIRA, ANDERSON RODRIGO; ZUMSTEIN GEORGETTO NAAL, ROSE MARY; NIKOLAOU, SOFIA. Novel binuclear mu-oxo diruthenium complexes combined with ibuprofen and ketoprofen: Interaction with relevant target biomolecules and anti-allergic potential. Journal of Inorganic Biochemistry, v. 153, p. 178-185, DEC 2015. (12/23245-6)

CACITA, NATACHA; NIKOLAOU, SOFIA. Studying the interaction between trinuclear ruthenium complexes and human serum albumin by means of fluorescence quenching. Journal of Luminescence, v. 169, p. 6-pg., 2016-01-01. (12/23245-6)

CLARO REIS, FELIPE COSTA; VIANA COELHO, JOANA STEFANI; PAZIN, WALLANCE MOREIRA; NIKOLAOU, SOFIA. A new homoleptic coordination compound of ruthenium and norfloxacin and its interaction with human serum albumin. Inorganic Chemistry Communications, v. 63, p. 96-100, JAN 2016. (12/23245-6)

Filed patent(s) as a result of this research project