| Grant number: | 12/21660-6 |
| Support Opportunities: | Regular Research Grants |
| Start date: | May 01, 2013 |
| End date: | April 30, 2015 |
| Field of knowledge: | Health Sciences - Dentistry |
| Principal Investigator: | Estela Kaminagakura Tango |
| Grantee: | Estela Kaminagakura Tango |
| Host Institution: | Instituto de Ciência e Tecnologia (ICT). Universidade Estadual Paulista (UNESP). Campus de São José dos Campos. São José dos Campos , SP, Brazil |
| Associated researchers: | Luiz Paulo Kowalski |
Abstract
Oral squamous cell carcinoma (OSCC) affects mainly patients between the 5th and 6th decades of life, being relatively rare in the young (d40 years). There is no report about the protein expression of drug metabolizing enzymes in OSCC in this group. The aim of this study is evaluate the protein expression of CYP1A1, CYP1B1, ALDH-1 and ALDH-2 by Tissue Microarray (TMA) technique. Forty primary OSCC from patients with £ 40 years of age treated in the Department of Head and Neck Surgery and Otorhinolaryngology, Hospital AC Camargo of Sao Paulo, from 1990 to 2007, will be assessed. These cases will be compared to 80 controls selected from patients aged e 50 who have tumors in similar clinical stage and topography. In both groups, the results will be correlated with clinical features and prognosis. The variables between groups compared using the x2 or Fisher exact test. The survival analyzes will be assessed by the Kaplan Meier and proportional hazards model of Cox. (AU)
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