Cancer of the penis, a real Brazilian problem: from morphology to molecular etiopathogenesis

• Grant number: 09/52088-3
• Support Opportunities: Research Projects - Thematic Grants
• Start date: October 01, 2009
• End date: September 30, 2014
• Field of knowledge: Health Sciences - Medicine - Pathological Anatomy and Clinical Pathology
• Principal Investigator: José Vassallo
• Grantee: José Vassallo
• Host Institution: A C Camargo Cancer Center. Fundação Antonio Prudente (FAP). São Paulo , SP, Brazil
• Pesquisadores principais: Ademar Lopes ; Paula Rahal
• Associated research grant(s): 14/11212-1 - 26th European Congress of Pathology, AR.EXT
• Associated scholarship(s): 09/11203-4 - Functional analysis of genes involved in carcinogenesis and development of penile cancer, BP.PD

Abstract

Carcinoma of the penis (CaPe) is a major health problem in Brazil, especially among economically underprivileged men in north/northeast regions. CaPe is a loco-regional disease and 5 year survival rate drops dramatically in patients with lymph node metastasis. Etiological factors include poor genital hygiene and phymosis, viral infection, ultraviolet radiation, smaking, balanitis xerotica obliterans, and chronic liquen. Although its diagnosis is relatively simple, patients usually seek for medical help in advanced stages of disease. Scientific knowledge, especially of its molecular aspects, is still scarce. The present grant proposal includes a number of studies addressing from clinic morphological aspects, to protein expression and molecular alterations in CaPe. It is intended to validate the WHO classification for these tumors and to establish prognostic variables of the variants of squamous cell carcinomas. A second group of projects deals with immunohistochemical detection of various markers, aiming to establish prognostic and predictive parameters which might foretell lymph node metastasis. Finally, molecular etiopathogenesis will be studied using gene expression techniques, evaluation of chromosomal copy numbers, and search for mutations or hypermethilation of specific genes. With this project we should be able to significantly contribute to a better understanding of this devastating disease. (AU)

Scientific publications

(10)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

MUNOZ, JUAN J.; DRIGO, SANDRA A.; KUASNE, HELLEN; VILLACIS, ROLANDO A. R.; MARCHI, FABIO A.; DOMINGUES, MARIA A. C.; LOPES, ADEMAR; SANTOS, TIAGO G.; ROGATTO, SILVIA R.. A comprehensive characterization of cell cultures and xenografts derived from a human verrucous penile carcinoma. TUMOR BIOLOGY, v. 37, n. 8, p. 11375-11384, AUG 2016. (09/52088-3, 10/51601-6, 09/14027-2)

BUSSO-LOPES, ARIANE F.; MARCHI, FABIO A.; KUASNE, HELLEN; SCAPULATEMPO-NETO, CRISTOVAM; TRINDADE-FILHO, JOSE CARLOS S.; DE JESUS, CARLOS MARCIO N.; LOPES, ADEMAR; GUIMARAES, GUSTAVO C.; ROGATTO, SILVIA R.. Genomic Profiling of Human Penile Carcinoma Predicts Worse Prognosis and Survival. Cancer Prevention Research, v. 8, n. 2, p. 149-156, FEB 2015. (09/06851-7, 09/52088-3, 10/51601-6, 11/03974-0)

MARCHI, FABIO ALBUQUERQUE; MARTINS, DAVID CORREA; BARROS-FILHO, MATEUS CAMARGO; KUASNE, HELLEN; BUSSO LOPES, ARIANE FIDELIS; BRENTANI, HELENA; SOUZA TRINDADE FILHO, JOSE CARLOS; GUIMARAES, GUSTAVO CARDOSO; FARIA, ELINEY F.; SCAPULATEMPO-NETO, CRISTOVAM; et al. Multidimensional integrative analysis uncovers driver candidates and biomarkers in penile carcinoma. SCIENTIFIC REPORTS, v. 7, JUL 27 2017. (09/52088-3, 10/51601-6)

MUNOZ, JUAN J.; DRIGO, SANDRA A.; BARROS-FILHO, MATEUS C.; MARCHI, FABIO A.; SCAPULATEMPO-NETO, CRISTOVAM; PESSOA, GUSTAVO S.; GUIMARAES, GUSTAVO C.; TRINDADE FILHO, JOSE CARLOS S.; LOPES, ADEMAR; ARRUDA, MARCO A. Z.; et al. Down-Regulation of SLC8A1 as a Putative Apoptosis Evasion Mechanism by Modulation of Calcium Levels in Penile Carcinoma. JOURNAL OF UROLOGY, v. 194, n. 1, p. 245-251, JUL 2015. (09/52088-3, 10/51601-6, 12/21344-7)

KUASNE, HELLEN; MARCHI, FABIO ALBUQUERQUE; ROGATTO, SILVIA REGINA; DE SYLLOS COLUS, ILCE MARA. Epigenetic Mechanisms in Penile Carcinoma. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 14, n. 6, p. 10791-10808, JUN 2013. (09/52088-3, 10/51601-6)

CALMON, MARILIA FREITAS; DE OLIVEIRA MOTA, MANLIO TASSO; BABETO, ERICA; CANDIDO, NATALIA MARIA; GIROL, ANA PAULA; MENDIBURU, CARLOS FABIAN; BONILHA, JANE LOPES; DUARTE SILVESTRE, RODRIGO VELLASCO; ROSA, BRUNO MIZIARA; THOME, JORGE ALBERTO; et al. Overexpression of ANXA1 in Penile Carcinomas Positive for High-Risk HPVs. PLoS One, v. 8, n. 1, JAN 14 2013. (09/52088-3, 09/11203-4)

KUASNE, HELLEN; BARROS-FILHO, MATEUS C.; BUSSO-LOPES, ARIANE; MARCHI, FABIO A.; PINHEIRO, MAISA; MUNOZ, JUAN J. M.; SCAPULATEMPO-NETO, CRISTOVAM; FARIA, ELINEY F.; GUIMARAES, GUSTAVO C.; LOPES, ADEMAR; et al. Integrative miRNA and mRNA analysis in penile carcinomas reveals markers and pathways with potential clinical impact. ONCOTARGET, v. 8, n. 9, p. 15294-15306, 2017. (13/03667-6, 10/51601-6, 09/52088-3)

THOMAZ DA SILVA AMANCIO, ALICE MUGLIA; DA CUNHA, ISABELA WERNECK; NEVES, JOSE IVANILDO; QUETZ, JOSIANE DA SILVA; CARRARO, DIRCE MARIA; ROCHA, RAFAEL MALAGOLI; ZEQUI, STENIO CASSIO; CUBILLA, ANTONIO LEOPOLDO; DA FONSECA, FRANCISCO PAULO; LOPES, ADEMAR; et al. Epidermal growth factor receptor as an adverse survival predictor in squamous cell carcinoma of the penis. HUMAN PATHOLOGY, v. 61, p. 97-104, MAR 2017. (09/52088-3, 12/09845-0)

KUASNE, HELLEN; DE SYLLOS COLUS, ILCE MARA; BUSSO, ARIANE FIDELIS; HERNANDEZ-VARGAS, HECTOR; BARROS-FILHO, MATEUS CAMARGO; MARCHI, FABIO ALBUQUERQUE; SCAPULATEMPO-NETO, CRISTOVAM; FARIA, ELINEY FERREIRA; LOPES, ADEMAR; GUIMARAES, GUSTAVO CARDOSO; et al. Genome-wide methylation and transcriptome analysis in penile carcinoma: uncovering new molecular markers. CLINICAL EPIGENETICS, v. 7, APR 18 2015. (09/52088-3, 10/51601-6)

BOVOLIM, GRAZIELE; DA COSTA, WALTER HENRIQUES; GUIMARAES, GUSTAVO CARDOSO; SOARES, FERNANDO AUGUSTO; DA CUNHA, ISABELA WERNECK. Mixed papillary-sarcomatoid carcinoma of the penis: report of an aggressive subtype. Virchows Archiv, v. 471, n. 6, p. 815-818, DEC 2017. (09/52088-3)