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Synthesis of natural products and analogs with potential application in the treatment of tropical diseases using combinatorial chemistry

Abstract

Combinatorial chemistry is the art and science of synthesizing and testing compounds for bioactivity en masse, instead of one by one, the aim being to discover drugs and materials more quickly and inexpensively than was formerly possible. The main objective of this project is the drug discovery for tropical diseases (Chagas' Disease and Leishmaniasis) using combinatorial chemistry and combinatorial technologies. More specifically, our goal is the solid-phase synthesis of natural products and analogs, such as flavonoids and alkaloids. These combinatorial libraries will be evaluated in vitro against Trypanossoma cruzi glycosomal glyceraldehyde-3-phosphate dehydrogenase (gGAPDH) and Leishmania tarentolae adenine phosphoribosyltransferase (APRT) enzymes. (AU)