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Schistosomicidal potential investigation of marine invertebrates belonging to the Ascidiacea family

Abstract

The search for new pharmaceutically active agents from natural sources has led to the discovery of many clinically useful drugs that play major roles in the treatment of human diseases. As a source of such compounds, the marine environment is showing vast potential, several marine-derived products being approved for used for against human diseases or ailments and many more in development. The aim of this research is to identify new structural classes of natural products produced by Brazilian marine organisms of the Class Ascidiacea (ascidians) and evaluate their potential as schistosomicidal and antimicrobial agents. Bioassay directed fractionation of extracts of the marine organisms will be used for the isolation of the active principal(s), which will then be subjected to extensive biological evaluation. Counter-screening against cytotoxicity and genotoxicity of the natural products will be also investigated. Bioassay guided fractionation will allow the isolation of the biologically active natural products, while the challenge of their structure solution will be achieved by extensive use of 2-dimensional NMR spectroscopy and mass spectrometry. Once structurally identified, the semi-synthesis of analogues will be undertaken to further explore structure-activity relationships. This project will contribute to the identification of novel classes of schistosomicidal and antimicrobial agents, diseases that are in desperate need for new chemotherapeutic agents. (AU)

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Scientific publications (6)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DE SOUZA, JONATHAN MESSIAS; CONCEICAO SANTOS, MARIO FERREIRA; NASCIMENTO PEDROSO, RITA CASSIA; PIMENTA, LETICIA PEREIRA; SIQUEIRA, KATIA APARECIDA; SOARES, MARCOS ANTONIO; DIAS, GUSTAVO MUNIZ; LINHARI RODRIGUE PIETRO, ROSEMEIRE CRISTINA; RAMOS, HENRIQUE PEREIRA; ANDRADE SILVA, MARCIO LUIS; PAULETTI, PATRICIA MENDONCA; SOLA VENEZIANI, RODRIGO CASSIO; AMBROSIO, SERGIO RICARDO; BRAUN, GLAUCIA HOLLAENDER; JANUARIO, ANA HELENA. Optimization of (-)-cubebin biotransformation to (-)-hinokinin by the marine fungus Absidia coerulea 3A9. Archives of Microbiology, v. 203, n. 7, p. 4313-4318, SEP 2021. Web of Science Citations: 0.
FILHO, LUIS C. KELLNER; ASSIS, RHENNER N. A.; SANTOS, ALINE O. DOS; TARGANSKI, SABRINA K.; SIQUEIRA, KATIA A.; MEDEIROS, LIVIA S. DE; ANGOLINI, CELIO F. F.; SILVA, FELIPE M. A. DA; SOARES, MARCOS A.; DIAS, GUSTAVO M.; SILVA, MARCIO L. A.; CUNHA, WILSON R.; PAULETTI, PATRICIA M.; KOOLEN, HECTOR H. F.; JANUARIO, ANA H. MOLECULAR NETWORKING-BASED DEREPLICATION OF AMBUIC ACID DERIVATIVES FROM THE MARINE FUNGUS PESTALOTIOPSIS SP. 4A11. Química Nova, SEP 2021. Web of Science Citations: 0.
DE SOUZA, JONATHAN MESSIAS; CONCEICAO SANTOS, MARIO FERREIRA; NASCIMENTO PEDROSO, RITA CASSIA; PIMENTA, LETICIA PEREIRA; SIQUEIRA, KATIA APARECIDA; SOARES, MARCOS ANTONIO; DIAS, GUSTAVO MUNIZ; LINHARI RODRIGUE PIETRO, ROSEMEIRE CRISTINA; RAMOS, HENRIQUE PEREIRA; ANDRADE SILVA, MARCIO LUIS; PAULETTI, PATRICIA MENDONCA; SOLA VENEZIANI, RODRIGO CASSIO; AMBROSIO, SERGIO RICARDO; BRAUN, GLAUCIA HOLLAENDER; JANUARIO, ANA HELENA. Optimization of (-)-cubebin biotransformation to (-)-hinokinin by the marine fungus Absidia coerulea 3A9. Archives of Microbiology, JUN 2021. Web of Science Citations: 0.
BRAUN, GLAUCIA H.; RAMOS, HENRIQUE P.; CANDIDO, ANA C. B. B.; PEDROSO, RITA C. N.; SIQUEIRA, KATIA A.; SOARES, MARCOS A.; DIAS, GUSTAVO M.; MAGALHAES, LIZANDRA G.; AMBROSIO, SERGIO R.; JANUARIO, ANA H.; PIETRO, ROSEMEIRE C. L. R. Evaluation of antileishmanial activity of harzialactone a isolated from the marine-derived fungus Paecilomyces sp. NATURAL PRODUCT RESEARCH, v. 35, n. 10, p. 1644-1647, MAY 19 2021. Web of Science Citations: 7.
KELLNER FILHO, LUIS C.; PICAO, BRUNO W.; SILVA, MARCIO L. A.; CUNHA, WILSON R.; PAULETTI, PATRICIA M.; DIAS, GUSTAVO M.; COPP, BRENT R.; BERTANHA, CAMILA S.; JANUARIO, ANA H. Bioactive Aliphatic Sulfates from Marine Invertebrates. MARINE DRUGS, v. 17, n. 9 SEP 2019. Web of Science Citations: 0.
BRAUN, GLAUCIA H.; RAMOS, HENRIQUE P.; CANDIDO, ANA C. B. B.; PEDROSO, RITA C. N.; SIQUEIRA, KATIA A.; SOARES, MARCOS A.; DIAS, GUSTAVO M.; MAGALHAES, LIZANDRA G.; AMBROSIO, SERGIO R.; JANUARIO, ANA H.; PIETRO, ROSEMEIRE C. L. R. Evaluation of antileishmanial activity of harzialactone a isolated from the marine-derived fungus Paecilomyces sp. NATURAL PRODUCT RESEARCH, v. 35, n. 10 MAY 2019. Web of Science Citations: 7.

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