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Molecular and Biochemical Analysis of Responses to Stress in Filamentous Fungi

Grant number: 96/01428-7
Support type:Research Projects - Thematic Grants
Duration: November 01, 1996 - April 30, 2001
Field of knowledge:Biological Sciences - Biochemistry
Principal Investigator:Hector Francisco Terenzi
Grantee:Hector Francisco Terenzi
Home Institution: Faculdade de Ciências Farmacêuticas de Ribeirão Preto (FCFRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
Associated grant(s):00/00613-2 - The rcaA gene from Aspergillus nidulans is required for camptothecin resistance and related to the cellular DNA damage reponse, AR.EXT
99/05885-1 - Cees Amjj Van Den Hondel | TNO Nutrition and Food Research Institute - Holanda, AV.EXT
98/15849-0 - David Perlin | New York Public Health Research Institute - Estados Unidos, AV.EXT
98/16579-6 - Catalase activity is necessary to heat-shock recovery in Aspergillus nidulans germilings, AR.EXT

Abstract

Coning and characterization of ubiquitin expression in A. nidulans under different stress conditions. Abnormal proteins arise continuously during any cellular stress process to avoid toxic levels abnormal proteins must be removed. A variety of biochemical and genetic evidence indicates that ubiquitin conjugation is a obligatory step in protein predegradation. We are interested in studying ubiquitin expression during different cellular stress processes in Aspergillus nidulans the main goals are: (i) cloning of the ubiquitin encoding genes of A. nidulans; (ii) characterization of ubiquitin gene expression under different stress conditions, and (iii) deletion or gene disruption of the ubiquitin gene. (AU)