The sensitive label free detection of disease markers using electrochemical immittance

• Grant number: 12/22820-7
• Support Opportunities: Research Projects - Thematic Grants
• Start date: August 01, 2013
• End date: January 31, 2019
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Analytical Chemistry
• Principal Investigator: Eduardo Maffud Cilli
• Grantee: Eduardo Maffud Cilli
• Host Institution: Instituto de Química (IQ). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil
• Pesquisadores principais:( Últimos ): Paulo Roberto Bueno
• Pesquisadores principais:( Antigos ): Eduardo Maffud Cilli
• Associated researchers: Eduardo Maffud Cilli ; Marcelo Mulato ; Maria Del Pilar Taboada Sotomayor
• Associated research grant(s): 17/50043-9 - Low-cost aptamer-based capacitance biosensors, AP.R SPRINT
• Associated scholarship(s): 17/13161-3 - Electrochemical biosensors for detection of HER2 protein linked to breast cancer, BP.IC; 16/17185-1 - Electrochemical glycoarray based on immittance functions as a technological platform in glycobiology, BP.PD; 16/24353-8 - Sensitive label free detection of disease markers using electrochemical immittance, BP.IC; + associated scholarships 16/24346-1 - Sensitive label free detection of disease markers using electrochemical immittance, BP.IC; 15/23241-9 - Capacitive Diagnostic Devices for Medical Applications, BE.PQ; 15/17332-1 - Label Free Electrochemical Multiplexing Prostate Cancer Diagnostics, BP.MS; 15/13359-2 - Sensitive label free detection systems of disease markers for clinical tests using electrochemical immittance, BP.PD; 15/13367-5 - Sensitive label free detection systems of disease markers for clinical tests using electrochemical immittance, BP.PD; 15/15682-5 - Sensitive label free detection of disease markers using electrochemical immittance, BP.IC; 15/15695-0 - The sensitive label free detection of disease markers using electrochemical immittance, BP.IC; 14/24559-0 - Multimodal array of enzymatic biosensors: potentiometric differential mode, optical and conductometric., BP.DR; 14/03039-8 - Sensitive label free detection of disease markers using electrochemical immittance, BP.PD; 13/26133-7 - Detection of changes related with breast cancer using charge sensors or mass sensors coupled to DNA monolayers, BP.DR - associated scholarships

Abstract

The electrochemical immittance is a concept recently developed by São Paulo State University (UNESP) and Oxford University with some joint patents deposited and some academic publications. It allows ultrasensitive label free detection of clinically important targets and binding affinity. Within this platform a biofunctionalized transducer surfaces (in microarray platform or not) can be generated using specific surface chemistries and binding moieties to target specific clinically important proteins associated with diseases and pathological disorders. The main purpose of this project is to continue to develop the concept and explore its functionality for clinical important markers using this concept to explore its applicability in UK and Brazilian patients. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

SANTOS, ADRIANO; BUENO, PAULO R.; DAVIS, JASON J.. A dual marker label free electrochemical assay for Flavivirus dengue diagnosis. BIOSENSORS & BIOELECTRONICS, v. 100, p. 519-525, FEB 15 2018. (12/22820-7)

HUDARI, FELIPE F.; BESSEGATO, GUILHERME G.; BEDATTY FERNANDES, FLAVIO C.; ZANONI, MARIA V. B.; BUENO, PAULO R.. Reagentless Detection of Low-Molecular-Weight Triamterene Using Self-Doped TiO2 Nanotubes. Analytical Chemistry, v. 90, n. 12, p. 7651-7658, JUN 19 2018. (15/13359-2, 15/18109-4, 14/03679-7, 12/22820-7)

PICCOLI, JULIA; HEIN, ROBERT; EL-SAGHEER, AFAF H.; BROWN, TOM; CILLI, EDUARDO M.; BUENO, PAULO R.; DAVIS, JASON J.. Redox Capacitive Assaying of C-Reactive Protein at a Peptide Supported Aptamer Interface. Analytical Chemistry, v. 90, n. 5, p. 3005-3008, MAR 6 2018. (15/02343-8, 13/07600-3, 12/22820-7)