| Grant number: | 13/50355-0 |
| Support Opportunities: | Regular Research Grants |
| Duration: | October 01, 2013 - September 30, 2014 |
| Field of knowledge: | Biological Sciences - Biophysics - Molecular Biophysics |
| Convênio/Acordo: | Ohio State University |
| Principal Investigator: | Roberto Kopke Salinas |
| Grantee: | Roberto Kopke Salinas |
| Principal researcher abroad: | Mark Foster |
| Institution abroad: | Ohio State University, Columbus, United States |
| Host Institution: | Instituto de Química (IQ). Universidade de São Paulo (USP). São Paulo , SP, Brazil |
| Associated research grant: | 11/07777-5 - Cyclic di-GMP signaling and the Type IV macromolecule secretion system in Xanthomonas citri, AP.TEM |
Abstract
The dynamic properties of many proteins are essential to their function, yet our understanding of protein dynamics, the time-dependent fluctuations in molecular structure, remain poorly understood. Protein dynamics play a role in critical cellular processes including metabolism, gene regulation and signal transduction. The proposed research plan aims to provide critical insights into the dynamic behavior of proteins through a combination of Nuclear Magnetic Resonance (NMR) spectroscopy, computational molecular dynamics simulations, and small angle X-ray scattering (SAXS). OSU and USP have complementary expertise and infrastructure for these studies, the proposed work will build upon existing collaboration, and will seed a new collaborative framework for studying the dynamics of proteins. (AU)
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