Activity of chalcones to control bacterial biofilm

• Grant number: 13/21642-0
• Support Opportunities: Regular Research Grants
• Start date: March 01, 2014
• End date: February 29, 2016
• Field of knowledge: Physical Sciences and Mathematics - Chemistry
• Principal Investigator: Marcia Nitschke
• Grantee: Marcia Nitschke
• Host Institution: Instituto de Química de São Carlos (IQSC). Universidade de São Paulo (USP). São Carlos , SP, Brazil
• Associated researchers: Andre Luiz Meleiro Porto

Abstract

When growing in biofilms microrganisms are more resistant to agents as antibiotics and disinfectants. Despite the great availability of antimicrobial compounds, there is a lack of molecules that are effective on controlling biofilms. Many biofilm-forming bacteria are related to diseases such as cystic fibrosis ( Pseudomonas aeruginosa) and tooth decay ( Streptococcus mutans) thus, the search for molecules that are effective on erradicate biofilms could represent an useful model to the development of new strategies to disease treatment. Natural and synthetic chalcones have potential anti-biofilm activity however, they have been little explored. The project aims to evaluate the potential of synthetic chalcones and derivatives flavanones and flavananols to control and erradicate biofilms of P. aeruginosa and S. mutans. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

DE MATOS, IARA LISBOA; NITSCHKE, MARCIA; MELEIRO PORTO, ANDRE LUIZ. Hydrogenation of Halogenated 2-Hydroxychalcones by Mycelia of Marine-Derived Fungus Penicillium raistrickii. MARINE BIOTECHNOLOGY, v. 21, n. 3, p. 430-439, JUN 2019. (13/21642-0)

DE MATOS, IARA LISBOA; NITSCHKE, MARCIA; PORTO, ANDRE LUIZ MELEIRO. B regioselective and chemoselective biotransformation of 2 `-hydroxychalcone derivatives by marine-derived fungi. BIOCATALYSIS AND BIOTRANSFORMATION, JUL 2021. (14/18257-0, 13/21642-0, 16/20155-7)

ANJOS, CHARLENE S.; LIMA, RAFAELY N.; PORTO, ANDRE L. M.. An overview of neonicotinoids: biotransformation and biodegradation by microbiological processes. Environmental Science and Pollution Research, v. 28, n. 28, p. 37082-37109, JUL 2021. (13/21642-0, 16/20155-7)