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Development of an integrated biosensor for monitoring changes of cellular metabolism

Abstract

The development of new devices for monitoring cell metabolism and disease diagnosis expanded the research on biosensors which together with nanotechnology mainly been enable the creation of new elements with high detection sensitivity, specificity, and multiplexing capacity for use in portable devices different areas. Thus, the monitoring of products secreted by the cells via biosensors have great interest in biomedical and health areas, therefore, cells transmit a wide variety of physical and chemical signals that are critical to the clinical diagnosis. Current studies evaluating biocompatibility and cell responses to physical or chemical stimuli are evaluated in microfluidic devices and electrochemical means. The enzymatic biosensors for the recognition of glucose, lactate and hydrogen peroxide are recurent used for evaluation of different diseases, but the construction of an integrated biosensor for monitoring these compounds is a challenge. Thus, the objective of this proposal is to develop an integrated platform for monitoring biosensor for detection of multi-analytes (glucose, lactate and hydrogen peroxide) to a device manufactured where the cellular microenvironment can be set accurately, enabling the evaluation of energy metabolism of cell cultures in the context of mimicking the cellular microenvironment and offering new insights into the molecular events metabolism. (AU)

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Scientific publications (4)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
VERDOODT, NIELS; BASSO, CAROLINE R.; ROSSI, BRUNA F.; PEDROSA, VALBER A. Development of a rapid and sensitive immunosensor for the detection of bacteria. Food Chemistry, v. 221, p. 1792-1796, APR 15 2017. Web of Science Citations: 16.
RECCO, LUCAS; CRULHAS, BRUNO P.; BASSO, CAROLINE R.; CASTRO, GUSTAVO R.; PEDROSA, VALBER A. Direct Electrochemical Detection of Estriol in Serum by Polymer Brushes Reinforced with Carbon Nanotubes. ECS JOURNAL OF SOLID STATE SCIENCE AND TECHNOLOGY, v. 5, n. 8, p. M3041-M3044, 2016. Web of Science Citations: 0.
RECCO, LUCAS C.; CRULHAS, BRUNO P.; PARRA, JOAO P. R. L. L.; PEDROSA, VALBER A. A new strategy for detecting dopamine in human serum using polymer brushes reinforced with carbon nanotubes. RSC ADVANCES, v. 6, n. 52, p. 47134-47137, 2016. Web of Science Citations: 6.
BASSO, CAROLINE R.; TOZATO, CLAUDIA C.; JUNIOR, JOAO PESSOA A.; PEDROSA, VALBER A. A fast and highly sensitive method for the detection of canine distemper virus by the naked eye. ANALYTICAL METHODS, v. 7, n. 6, p. 2264-2267, 2015. Web of Science Citations: 9.

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