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The role of physical activity in the prevention of prostate hyperplasia and bladder dysfunction in rats with metabolic syndrome

Grant number: 14/08368-0
Support type:Regular Research Grants
Duration: October 01, 2014 - September 30, 2016
Field of knowledge:Health Sciences - Medicine - Surgery
Principal Investigator:Alberto Azoubel Antunes
Grantee:Alberto Azoubel Antunes
Home Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Assoc. researchers: André Matos de Oliveira ; Fernando Mello Fróes da Fonseca ; Kátia Ramos Moreira Leite ; Miguel Srougi ; Sabrina Thalita dos Reis Faria

Abstract

The high prevalence of BPH in the general population demands the importance of proper understanding and potentially modifiable factors for its development. The first step to knowledge of the exact mechanisms by which SM stimulates prostate growth and structural changes in the bladder is to create optimal conditions for stimulation through an experimental model and to investigate the histological and molecular changes in prostate and bladder tissue. These conditions are difficult to be reproduced in a clinical study in humans due to the difficulty in gathering individuals with homogeneous clinical characteristics. Thus, we believe that the ideal place to understand the relationship between MetS and BPH/LUTS is to study the potential biological mechanisms involved in experimental models. Finally, to understand the mechanisms by which physical activity interferes with the pathogenic mechanisms of BPH and overactive bladder, it is necessary to introduce in this experimental model, a model of physical activity (AU)