Melatonin and its cytoprotective effect on the maturation of mammalian oocytes
| Grant number: | 14/17830-9 |
| Support type: | Regular Research Grants |
| Duration: | November 01, 2014 - October 31, 2017 |
| Field of knowledge: | Agronomical Sciences - Veterinary Medicine |
| Principal Investigator: | Lia de Alencar Coelho |
| Grantee: | Lia de Alencar Coelho |
| Home Institution: | Faculdade de Zootecnia e Engenharia de Alimentos (FZEA). Universidade de São Paulo (USP). Pirassununga , SP, Brazil |
| Assoc. researchers: | Fernanda Gaspar Do Amaral ; José Cipolla Neto ; Luciano Andrade Silva ; Ricardo de Francisco Strefezzi ; Solange Castro Afeche |
Abstract
The research aimed to evaluate the effect of melatonin on the expression of MPF proteins in rat; evaluate the effect of gonadotrophins added to in vitro maturation medium on the activity of melatonin forming enzymes (Aanat and Asmt) in rat; evaluate the effect of melatonin added to in vitro maturation medium on the maturation rates, expression of melatonin receptor, gonadotrophin and apoptosis genes in mares. (AU)