Advanced search
Start date

Role of IL-33 in skin squamous cell carcinoma

Grant number: 14/06215-1
Support Opportunities:Regular Research Grants
Duration: November 01, 2014 - October 31, 2016
Field of knowledge:Biological Sciences - Immunology - Cellular Immunology
Principal Investigator:Ana Paula Campanelli
Grantee:Ana Paula Campanelli
Host Institution: Faculdade de Odontologia de Bauru (FOB). Universidade de São Paulo (USP). Bauru , SP, Brazil
Associated researchers: Karen Angélica Cavassani


Squamous cell carcinoma (SCC) is the second most common form of skin cancer and is most commonly observed in photo-exposed areas of the body. SCCs localized in the head and/or neck region are often characterized by lymphatic dissemination but the mechanism(s) involved in the progression of this tumor are unknown. Recent studies have shown that there is a direct association between a Th1-related immune response and a better prognosis in patients with SCC. These findings have led us to hypothesize that the protective Th1-type immune response against SCC might be impaired by endogenous immunoregulatory factors. One example is ST2L, which we have recently noted that when it is activated by the cytokine IL-33, Th1-type innate immune responses are impaired (1). Moreover, ST2L is constitutively expressed on natural killer (NK) cells and macrophages but its role in these cells during tumor progression remains to be fully elucidated. Based on these findings, we have formulated the hypothesis that immunoregulatory signaling mediated via IL-33/ST2L impairs the Th1-type immune response thereby leaving the development of SCC. (AU)

Articles published in Agência FAPESP Newsletter about the research grant:
Articles published in other media outlets (0 total):
More itemsLess items

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
AMOR, NADIA GHINELLI; DA SILVA SANTOS, PAULO SERGIO; CAMPANELLI, ANA PAULA. The Tumor Microenvironment in SCC: Mechanisms and Therapeutic Opportunities. FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, v. 9, . (18/10529-2, 14/06215-1)

Please report errors in scientific publications list by writing to: