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Use of drugs containing nanocarriers with photosensitizers and/or other active compounds applied to cell therapy and treatment of central nervous system disorders

Grant number: 13/50181-1
Support type:Research Projects - Thematic Grants
Duration: June 01, 2015 - December 31, 2020
Field of knowledge:Health Sciences - Pharmacy
Principal Investigator:Antonio Claudio Tedesco
Grantee:Antonio Claudio Tedesco
Home Institution: Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto (FFCLRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
Co-Principal Investigators:Sergio Cavalheiro
Associated grant(s):18/01608-6 - 19th European symposium on Radiopharmacy and radiopharmaceuticals, AR.EXT
17/01273-1 - Multi-user equipament approved in grants 13/50181-1:spectrofluorometer model RF-6000 Shmadzu and accessories, AP.EMU
17/04915-4 - Multi-user equipament approved in grants 13/50181-1: Bio-Scaffold printer 3D 3axis com precisão nos eixos XYZ- 3D, AP.EMU
Associated scholarship(s):19/04801-4 - Use of nanocarriers containing photosensitizing drugs and other actives applied to cell therapy and treatment of pathologies of the central nervous system, BP.TT
18/24004-9 - Nanocarriers loaded with photosensitizers and others drugs derived of growth factors applied to photodynamic processes in treatment of central nervous system diseases, BP.PD
15/18684-9 - Use of drugs containing nanocarriers with photosensitizers and/or other active compounds applied to cell therapy and treatment of central nervous system disorders, BP.PD
14/11870-9 - Sensitizing cancer cell lines to photodynamic therapy through inhibition of protein APE1, BP.PD

Abstract

The central nervous system (CNS) is composed of astrocytes (50%), oligodendrocytes (40%), microglia (5%) and ependymal cells (5%) which provide structural and functional support to neurons. In particular glial tumors (glioma or, glioblastoma) are among ... (AU)

Articles published in other media outlets (28 total):
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Nanotecnologia contra câncer cerebral mais agressivo é testada na USP 
Nova estratégia para tratar o tipo mais agressivo de câncer cerebral é testada na USP 
Nova estratégia para tratar o tipo mais agressivo de câncer cerebral é testada na USP 
Nova estratégia contra o câncer 
Nova estratégia para tratar o tipo mais agressivo de câncer cerebral é testada na USP 
Novo tratamento para câncer cerebral agressivo é testado na USP 
New strategy for treating the most aggressive type of brain cancer is tested at USP 
Nova estratégia para tratar o tipo mais agressivo de câncer cerebral é testada na USP 
New strategy for treating the most aggressive type of brain cancer 
Nova estratégia para tratar o tipo mais agressivo de câncer cerebral é testada na USP 
Nova estratégia para tratar o tipo mais agressivo de câncer cerebral é testada na USP 
Novo tratamento para câncer cerebral agressivo é testado na USP 
Nova estratégia para tratar o tipo mais agressivo de câncer cerebral é testada na USP 
New treatment for aggressive brain cancer is tested at USP 
Nova estratégia para tratar o tipo mais agressivo de câncer cerebral é testada na USP 
Nova estratégia para tratar o tipo mais agressivo de câncer cerebral é testada na USP 
Nova estratégia para tratar o tipo mais agressivo de câncer cerebral é testada na USP 
New strategy for treating the most aggressive type of brain cancer is tested at USP 
New strategy for treating the most aggressive type of brain cancer is tested at USP 
Researchers develop new strategy for treating the most aggressive type of brain cancer 
New strategy for treating the most aggressive type of brain cancer is tested at USP 
New strategy for treating the most aggressive type of brain cancer is tested at USP 
New strategy for treating the most aggressive type of brain cancer is tested at USP 
New strategy for treating the most aggressive type of brain cancer 
New strategy for treating the most aggressive type of brain cancer 
New strategy for treating the most aggressive type of brain cancer 
New strategy for treating the most aggressive type of brain cancer 
O potencial do vírus zika pode combater tumores no cérebro 

Scientific publications (21)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
SOUZA, CARLA; PELLOSI, DIOGO SILVA; TEDESCO, ANTONIO CLAUDIO. Prodrugs for targeted cancer therapy. EXPERT REVIEW OF ANTICANCER THERAPY, v. 19, n. 6, p. 483-502, JUN 3 2019. Web of Science Citations: 0.
REZENDE, NAYARA; JAYME, CRISTIANO CERON; BRASSESCO, MARIA SOL; TEDESCO, ANTONIO CLAUDIO; DE OLIVEIRA, HARLEY FRANCISCO. Standardization of a resazurin-based assay for the evaluation of metabolic activity in oral squamous carcinoma and glioblastoma cells. Photodiagnosis and Photodynamic Therapy, v. 26, p. 371-374, JUN 2019. Web of Science Citations: 1.
CALORI, ITALO RODRIGO; JAYME, CRISTIANO CERON; UENO, LEONARDO TSUYOSHI; CORRETO MACHADO, FRANCISCO BOLIVAR; TEDESCO, ANTONIO CLAUDIO. Theoretical and experimental studies concerning monomer/aggregates equilibrium of zinc phthalocyanine for future photodynamic action. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, v. 214, p. 513-521, MAY 5 2019. Web of Science Citations: 0.
CASTILHO-FERNANDES, ANDRIELLE; LOPES, TADLA G.; FERREIRA, FERNANDO U.; REZENDE, NAYARA; SILVA, VALERIA F.; PRIMO, FERNANDO L.; FONTES, APARECIDA MARIA; RIBEIRO-SILVA, ALFREDO; TEDESCO, ANTONIO CLAUDIO. Adipogenic differentiation of murine bone marrow mesenchymal stem cells induced by visible light via photo- induced biomodulation. Photodiagnosis and Photodynamic Therapy, v. 25, p. 119-127, MAR 2019. Web of Science Citations: 1.
PELLOSI, DIOGO S.; PAULA, LEONARDO B.; DE MELO, MARYANNE T.; TEDESCO, ANTONIO C. Targeted and Synergic Glioblastoma Treatment: Multifunctional Nanoparticles Delivering Verteporfin as Adjuvant Therapy for Temozolomide Chemotherapy. MOLECULAR PHARMACEUTICS, v. 16, n. 3, p. 1009-1024, MAR 2019. Web of Science Citations: 2.
PELLOSI, DIOGO SILVA; MACAROFF, PATRICIA PEREIRA; MORAIS, PAULO CESAR; TEDESCO, ANTONIO CLAUDIO. Magneto low-density nanoemulsion (MLDE): A potential vehicle for combined hyperthermia and photodynamic therapy to treat cancer selectively. Materials Science & Engineering C-Materials for Biological Applications, v. 92, p. 103-111, NOV 1 2018. Web of Science Citations: 4.
JAYME, CRISTIANO CERON; CALORI, ITALO RODRIGO; FREIRE CUNHA, ELISE MARQUES; TEDESCO, ANTONIO CLAUDIO. Evaluation of aluminum phthalocyanine chloride and DNA interactions for the design of an advanced drug delivery system in photodynamic therapy. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, v. 201, p. 242-248, AUG 5 2018. Web of Science Citations: 4.
FERREIRA-SILVA, VALERIA; PRIMO, FERNANDO L.; BAQUI, MUNIRA M. A.; MAGALHAES, DANIELLE A. R.; ORELLANA, MARISTELA D.; CASTILHO-FERNANDES, ANDRIELLE; CRUZ, MARIO C.; CAMARA, NIEHLS O. S.; COVAS, DIMAS T.; TEDESCO, ANTONIO C. Beneficial Role of Low-Intensity Laser Irradiation on Neural beta-tubulin III Protein Expression in Human Bone Marrow Multipotent Mesenchymal Stromal Cells. STEM CELL REVIEWS AND REPORTS, v. 14, n. 4, p. 585-598, AUG 2018. Web of Science Citations: 2.
SIMIONI, ANDREZA RIBEIRO; CARVALHO DE JESUS, PRISCILA COSTA; TEDESCO, ANTONIO CLAUDIO. Layer-by-layer hollow photosensitizer microcapsule design via a manganese carbonate hard template for photodynamic therapy in cells. Photodiagnosis and Photodynamic Therapy, v. 22, p. 169-177, JUN 2018. Web of Science Citations: 4.
JAYME, CRISTIANO CERON; DE PAULA, LEONARDO BARCELOS; REZENDE, NAYARA; CALORI, ITALO RODRIGO; FRANCHI, LEONARDO PEREIRA; TEDESCO, ANTONIO CLAUDIO. DNA polymeric films as a support for cell growth as a new material for regenerative medicine: Compatibility and applicability. Experimental Cell Research, v. 360, n. 2, p. 404-412, NOV 15 2017. Web of Science Citations: 4.
CASTILHO-FERNANDES, ANDRIELLE; LOPES, TACILA G.; PRIMO, FERNANDO L.; PINTO, MARCELO R.; TEDESCO, ANTONIO C. Photodynamic process induced by chloro-aluminum phthalocyanine nanoemulsion in glioblastoma. Photodiagnosis and Photodynamic Therapy, v. 19, p. 221-228, SEP 2017. Web of Science Citations: 7.
DAVANZO, NATHALIA NOSSI; PELLOSI, DIOGO SILVA; FRANCHI, LEONARDO PEREIRA; TEDESCO, ANTONIO CLAUDIO. Light source is critical to induce glioblastoma cell death by photodynamic therapy using chloro-aluminiumphtalocyanine albumin-based nanoparticles. Photodiagnosis and Photodynamic Therapy, v. 19, p. 181-183, SEP 2017. Web of Science Citations: 6.
LEANDRO, FERNANDA Z.; MARTINS, JULIA; FONTES, APARECIDA M.; TEDESCO, ANTONIO C. Evaluation of theranostic nanocarriers for near-infrared imaging and photodynamic therapy on human prostate cancer cells. COLLOIDS AND SURFACES B-BIOINTERFACES, v. 154, p. 341-349, JUN 1 2017. Web of Science Citations: 8.
GOTO, PATRICIA L.; SIQUEIRA-MOURA, MARIGILSON P.; TEDESCO, ANTONIO C. Application of aluminum chloride phthalocyanine-loaded solid lipid nanoparticles for photodynamic inactivation of melanoma cells. International Journal of Pharmaceutics, v. 518, n. 1-2, p. 228-241, FEB 25 2017. Web of Science Citations: 12.
PELLOSI, DIOGO SILVA; CALORI, ITALO RODRIGO; DE PAULA, LEONARDO BARCELOS; HIOKA, NOBORU; QUAGLIA, FABIANA; TEDESCO, ANTONIO CLAUDIO. Multifunctional theranostic Pluronic mixed micelles improve targeted photoactivity of Verteporfin in cancer cells. Materials Science & Engineering C-Materials for Biological Applications, v. 71, p. 1-9, FEB 1 2017. Web of Science Citations: 15.
DE PAULA, L. B.; PRIMO, F. L.; PINTO, M. R.; MORAIS, P. C.; TEDESCO, A. C. Evaluation of a chloroaluminium phthalocyanine-loaded magnetic nanoemulsion as a drug delivery device to treat glioblastoma using hyperthermia and photodynamic therapy. RSC ADVANCES, v. 7, n. 15, p. 9115-9122, 2017. Web of Science Citations: 11.
PELLOSI, DIOGO SILVA; CARVALHO DE JESUS, PRISCILA DA COSTA; TEDESCO, ANTONIO CLAUDIO. Spotlight on the delivery of photosensitizers: different approaches for photodynamic-based therapies. Expert Opinion on Drug Delivery, v. 14, n. 12, p. 1395-1406, 2017. Web of Science Citations: 8.
FRANCHI, LEONARDO PEREIRA; AMANTINO, CAMILA F.; MELO, MARYANNE T.; DE LIMA MONTALDI, ANA PAULA; PRIMO, FERNANDO L.; TEDESCO, ANTONIO CLAUDIO. In vitro effects of photodynamic therapy induced by chloroaluminum phthalocyanine nanoemulsion. Photodiagnosis and Photodynamic Therapy, v. 16, p. 100-105, DEC 2016. Web of Science Citations: 4.
CALORI, ITALO RODRIGO; TEDESCO, ANTONIO CLAUDIO. Lipid vesicles loading aluminum phthalocyanine chloride: Formulation properties and disaggregation upon intracellular delivery. JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY, v. 160, p. 240-247, JUL 2016. Web of Science Citations: 12.
JAYME, CRISTIANO CERON; CALORI, ITALO RODRIGO; TEDESCO, ANTONIO CLAUDIO. Spectroscopic analysis of aluminum chloride phthalocyanine in binary water/ethanol systems for the design of a new drug delivery system for photodynamic therapy cancer treatment. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, v. 153, p. 178-183, JAN 15 2016. Web of Science Citations: 21.
SILVA, E. P. O.; FRANCHI, L. P.; TEDESCO, A. C. Chloro-aluminium phthalocyanine loaded in ultradeformable liposomes for photobiology studies on human glioblastoma. RSC ADVANCES, v. 6, n. 83, p. 79631-79640, 2016. Web of Science Citations: 6.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.