Development and evaluation of Consumable-free planar microfluidic modulators for comprehensive two-dimensional gas chromatography

• Grant number: 15/05059-9
• Support Opportunities: Regular Research Grants
• Start date: July 01, 2015
• End date: June 30, 2017
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Analytical Chemistry
• Principal Investigator: Leandro Wang Hantao
• Grantee: Leandro Wang Hantao
• Host Institution: Centro Nacional de Pesquisa em Energia e Materiais (CNPEM). Ministério da Ciência, Tecnologia e Inovação (Brasil). Campinas , SP, Brazil
• Associated researchers: Angelo Luiz Gobbi ; Renato Sousa Lima

Abstract

The analysis of the volatile and semi-volatile fraction of complex samples remains a challenge to separation scientists due to the overwhelming number of sample components and the wide range of physical and chemical properties exhibited by the analytes. Among all instrumental techniques available today, comprehensive two-dimensional gas chromatography is considered the most remarkable and valuable technique for the separation, detection, and identification of organic compounds, applicable to any sample (e.g., biological or food samples and petrochemical derivatives). However, the main factor that still hampers its wide spread use in routine analysis is the aggravated cost with consumables (e.g., liquid nitrogen). Hence, the present research proposal will aim at the development and evaluation of consumable-free planar microfluidic modulators as an alternative to commercially available cryogenic modulators. To accomplish this goal, we will explore the fundamentals of chromatography and combine them to the state-of-art in heat transfer technology used in high efficiency electronic devices. The prototypes will consist of two-stage thermal modulators by combining alternated steps of sorptive trapping and thermal desorption. Analyte trapping will occur by sorption to a thick non-selective stationary phase (e.g., polydimethylsiloxane) operated at low temperatures to favor the distribution constant of the analytes in the two-phase system. The thermal desorption of the analytes, on the other hand, will be accomplished by exploring microfabricated resistive heating systems imparted with reduced thermal mass. In addition, among the numerous experimental parameters that will be evaluated and optimized, we highlight the geometry of the modulation channels, as it will play an important role in heat transfer and, especially, to the average linear velocity of the chromatographic bands inside the microfluidic modulator. Lastly, the results of this work will be crucial to understand thermal and sorptive modulation in microfabricated systems for GC×GC. We hope that the scientific knowledge generated by this research will culminate in the development of an economical and marketable interface for GC×GC. (AU)

Scientific publications

(9)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

BELINATO DE SOUZA, JOAO R.; DIAS, FERNANDA F. G.; CALIMAN, JAQUELINE D.; AUGUSTO, FABIO; HANTAO, LEANDRO W.. Opportunities for green microextractions in comprehensive two-dimensional gas chromatography / mass spectrometry-based metabolomics - A review. Analytica Chimica Acta, v. 1040, p. 1-18, DEC 21 2018. (11/51896-9, 17/25490-1, 15/05059-9, 16/20547-2)

KATAOKA, ERICA M.; MURER, RUI C.; SANTOS, JANDYSON M.; CARVALHO, ROGERIO M.; EBERLIN, MARCOS N.; AUGUSTO, FABIO; POPPI, RONEI J.; GOBBI, ANGELO L.; HANTAO, LEANDRO W.. Simple, Expendable, 3D-Printed Microfluidic Systems for Sample Preparation of Petroleum. Analytical Chemistry, v. 89, n. 6, p. 3460-3467, MAR 21 2017. (13/19161-4, 15/05059-9, 14/00228-4)

MARIANO, MARCOS; HANTAO, LEANDRO WANG; BERNARDES, JULIANA DA SILVA; STRAUSS, MATHIAS. Microstructural characterization of nanocellulose foams prepared in the presence of cationic surfactants. Carbohydrate Polymers, v. 195, p. 153-162, SEP 1 2018. (15/05059-9, 16/04514-7)

HIGA, KAREN M.; GUILHEN, AUGUSTO; VIEIRA, LUIS C. S.; CARVALHO, ROGERIO M.; POPPI, RONEI J.; BAPTISTAO, MARIANA; GOBBI, ANGELO L.; LIMA, RENATO S.; HANTAO, LEANDRO W.. Simple Solid-Phase Extraction Method for High Efficiency and Low Cost Crude Oil emulsification. ENERGY & FUELS, v. 30, n. 6, p. 4667-4675, JUN 2016. (15/05059-9, 14/00228-4)

POLLO, BRENO J.; ALEXANDRINO, GUILHERME L.; AUGUSTO, FABIO; HANTAO, LEANDRO W.. The impact of comprehensive two-dimensional gas chromatography on oil & gas analysis: Recent advances and applications in petroleum industry. TRAC-TRENDS IN ANALYTICAL CHEMISTRY, v. 105, p. 202-217, AUG 2018. (15/08201-0, 15/05059-9)

PASSINI, RODRIGO; PIERONE, DANILO; GOBBI, ANGELO L.; HANTAO, LEANDRO W.. Flow Modulated Comprehensive Two-Dimensional Gas Chromatography Part I - Low Duty Cycle Modulation of Hidroprocessed Vegetable Oil. BRAZILIAN JOURNAL OF ANALYTICAL CHEMISTRY, v. 6, n. 24, p. 74-81, JUL-SEP 2019. (15/05059-9, 17/25490-1)

CRUCELLO, JULIANA; MIRON, LUIZ F. O.; FERREIRA, VICTOR H. C.; NAN, HE; MARQUES, MARCIA O. M.; RITSCHEL, PATRICIA S.; ZANUS, MAURO C.; ANDERSON, JARED L.; POPPI, RONEI J.; HANTAO, LEANDRO W.. Characterization of the aroma profile of novel Brazilian wines by solid-phase microextraction using polymeric ionic liquid sorbent coatings. ANALYTICAL AND BIOANALYTICAL CHEMISTRY, v. 410, n. 19, p. 4749-4762, JUL 2018. (15/05059-9)

MUCEDOLA, VANESSA; VIEIRA, LUIS C. S.; PIERONE, DANILO; GOBBI, ANGELO L.; POPPI, RONEI J.; HANTAO, LEANDRO W.. Thermal desorption modulation for comprehensive two-dimensional gas chromatography using a simple and inexpensive segmented-loop fluidic interface. Talanta, v. 164, p. 470-476, MAR 1 2017. (15/05059-9, 14/00228-4)

OLIVEIRA, RENATA M. A.; HENRIQUES, JULCELLY D. O.; SARTORATTO, ADILSON; MACIEL, MARIA R. W.; MARTINEZ, PATRICIA F. M.. Evaluation of Limonene in sugarcane wax extraction. SUSTAINABLE CHEMISTRY AND PHARMACY, v. 27, p. 11-pg., 2022-03-07. (15/05059-9, 15/25384-1)

Filed patent(s) as a result of this research project