Synthesis and characterization of conjugates obtained from Streptococcus pneumoniae capsular polysaccharide and PspA as vaccines candidates

• Grant number: 15/07225-3
• Support type: Regular Research Grants
• Duration: July 01, 2015 - December 31, 2017
• Field of knowledge: Biological Sciences - Biochemistry - Chemistry of Macromolecules
• Principal researcher: Giovana Cappio Barazzone
• Grantee: Giovana Cappio Barazzone
• Home Institution: Instituto Butantan. Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil
• Assoc. researchers: Viviane Maimoni Gonçalves

Abstract

The conjugate vaccines are nowadays one of the most effective ways to prevent diseases caused by pathogens like Streptococcus pneumoniae, Haemophilus influenzae and Neisseria meningitidis. The World Health Organization recommends using these vaccines. The S. pneumoniae is the most common cause of bacterial pneumonia, sinusitis and otitis media in children.The development of alternative methods to obtain conjugate vaccines aiming to improve their availability, as well as increasing the numbers of producers mainly in low-income countries, is of great importance. Within this objective the Centro de Biotecnologia do Instituto Butantan has been studying the synthesis of these conjugates and their applicability as vaccines. In this sense, this project proposes to continue the studies regarding the conjugate synthesis between S. pneumoniae capsular polysaccharide and pneumococcal surface proteins as carriers, aiming to raise the vaccinal coverage. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

DA SILVA, MIRIAM A.; CONVERSO, THIAGO R.; GONCALVES, VIVIANE M.; LEITE, LUCIANA C. C.; TANIZAKI, MARTHA M.; BARAZZONE, GIOVANA C. Conjugation of PspA4Pro with Capsular Streptococcus pneumoniae Polysaccharide Serotype 14 Does Not Reduce the Induction of Cross-Reactive Antibodies. Clinical and Vaccine Immunology, v. 24, n. 8 AUG 2017. Web of Science Citations: 2.