Stem cells, regeneration, and the evolution of coloniality in ascidians

• Grant number: 15/50164-5
• Support Opportunities: Research Grants - Young Investigators Grants
• Start date: August 01, 2015
• End date: July 31, 2019
• Field of knowledge: Biological Sciences - Zoology - Morphology of Recent Groups
• Agreement: ANR
• Principal Investigator: Federico David Brown Almeida
• Grantee: Federico David Brown Almeida
• Principal researcher abroad: Stefano Tiozzo
• Institution abroad: Université Pierre et Marie Curie (Paris 6), France
• Host Institution: Instituto de Biociências (IB). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated research grant(s): 18/50017-0 - Clonal strategies in subantartic and subtropical colonial ascidians, AP.R SPRINT; 16/19362-8 - Anthony De Tomaso (UCSB) research visit: stem cells, budding, and the evolution of coloniality in ascidians, AV.EXT
• Associated scholarship(s): 19/06927-5 - Forging technical breakthroughs for colonial ascidian developmental biology research: transgenesis and mutagenesis in Botryllus schlosseri, BE.PQ; 18/09597-3 - Ascidian collections, laboratory cultures, and descriptions of budding, BP.TT; 17/13758-0 - ncRNAs in colonial ascidians, BP.MS; 16/07607-6 - Circulatory stem cells of styelid ascidians, BP.MS; 15/22650-2 - Evolution developmental modes in colonial ascidians, BP.DD

Abstract

Many chordate species have lost the ability to regenerate complete adult structures. However, marine chordates with sedentary and colonial life forms, e.g. tunicates, have remarkable potentials of regeneration possibly related to their ability to reproduc (AU)

Scientific publications

(16)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

MOREANO-ARROBO, LOLA; PEREZ, OSCAR D.; BROWN, FEDERICO D.; OYARZUN, FERNANDA X.; CANALES-AGUIRRE, CRISTIAN B.. The ``Mexican dancer{''} in Ecuador: molecular confirmation, embryology and planktotrophy in the sea slug Elysia diomedea. INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY, v. 65, n. 4-6, 2, p. 323-332, 2021. (18/50017-0, 15/50164-5, 19/06927-5)

HIEBERT, LAUREL S.; VIEIRA, LEANDRO M.; TIOZZO, STEFANO; SIMPSON, CARL; GROSBERG, RICHARD K.; MIGOTTO, ALVARO E.; MORANDINI, ANDRE C.; BROWN, FEDERICO D.. From the individual to the colony: Marine invertebrates as models to understand levels of biological organization. JOURNAL OF EXPERIMENTAL ZOOLOGY PART B-MOLECULAR AND DEVELOPMENTAL EVOLUTION, v. 336, n. 3, APR 2021. (18/05923-3, 15/50164-5, 19/06927-5, 18/50017-0, 15/14052-8)

ALIE, ALEXANDRE; HIEBERT, LAUREL SKY; SIMION, PAUL; SCELZO, MARTA; PRUNSTER, MARIA MANDELA; LOTITO, SONIA; DELSUC, FREDERIC; DOUZERY, EMMANUEL J. P.; DANTEC, CHRISTELLE; LEMAIRE, PATRICK; et al. Convergent Acquisition of Nonembryonic Development in Styelid Ascidians. Molecular Biology and Evolution, v. 35, n. 7, p. 1728-1743, JUL 2018. (15/14052-8, 15/50164-5)

PRUNSTER, MARIA MANDELA; RICCI, LORENZO; BROWN, FEDERICO D.; TIOZZO, STEFANO. Modular co-option of cardiopharyngeal genes during non-embryonic myogenesis. EVODEVO, v. 10, MAR 5 2019. (15/50164-5)

BROWN, FEDERICO D.. Evolution of animal coloniality and modularity: Emerging themes. JOURNAL OF EXPERIMENTAL ZOOLOGY PART B-MOLECULAR AND DEVELOPMENTAL EVOLUTION, v. 336, n. 3, p. 4-pg., 2021-03-10. (19/06927-5, 18/50017-0, 15/50164-5)

VELANDIA-HUERTO, CRISTIAN A.; GITTENBERGER, ADRIAAN A.; BROWN, FEDERICO D.; STADLER, PETER F.; BERMUDEZ-SANTANA, CLARA I.. Automated detection of ncRNAs in the draft genome sequence of a colonial tunicate: the carpet sea squirt Didemnum vexillum. BMC Genomics, v. 17, AUG 30 2016. (15/50164-5)

BROWN, FEDERICO D.; ISHENGOMA, EDSON; MAYER, GEORG; PABON-MORA, NATALIA; SANTOS, M. EMILIA; SEARS, KAREN E.; DE SENA OLIVEIRA, IVO. Uncovering developmental diversity in the field. DEVELOPMENT, v. 151, n. 16, p. 6-pg., 2024-08-01. (15/50164-5, 19/06927-5, 18/50017-0)

SAAD, LUIZA O.; COOKE, THOMAS F.; ATABAY, KUTAY D.; REDDIEN, PETER W.; BROWN, FEDERICO D.. Reduced adult stem cell fate specification led to eye reduction in cave planarians. NATURE COMMUNICATIONS, v. 16, n. 1, p. 22-pg., 2025-01-02. (18/06418-0, 15/50164-5, 19/18147-4)

JIMENEZ-MERINO, JUAN; DE ABREU, ISADORA SANTOS; HIEBERT, LAUREL S.; ALLODI, SILVANA; TIOZZO, STEFANO; DE BARROS, CINTIA M.; BROWN, FEDERICO D.. Putative stem cells in the hemolymph and in the intestinal submucosa of the solitary ascidian Styela plicata. EVODEVO, v. 10, n. 1, NOV 25 2019. (19/06927-5, 16/07607-6, 15/50164-5, 15/14052-8, 18/05923-3)

HIEBERT, LAUREL SKY; VIEIRA, EDSON A.; DIAS, GUSTAVO M.; TIOZZO, STEFANO; BROWN, FEDERICO D.. Colonial ascidians strongly preyed upon, yet dominate the substrate in a subtropical fouling community. PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, v. 286, n. 1899, MAR 20 2019. (15/50164-5, 15/14052-8, 16/17647-5)

MARCELLINI, SYLVAIN; GONZALEZ, FAVIO; SARRAZIN, ANDRES F.; PABON-MORA, NATALIA; BENITEZ, MARIANA; PINEYRO-NELSON, ALMA; REZENDE, GUSTAVO L.; MALDONADO, ERNESTO; SCHNEIDER, PATRICIA NEIVA; GRIZANTE, MARIANA B.; et al. Evolutionary Developmental Biology (Evo-Devo) Research in Latin America. JOURNAL OF EXPERIMENTAL ZOOLOGY PART B-MOLECULAR AND DEVELOPMENTAL EVOLUTION, v. 328, n. 1-2, p. 5-40, JAN-FEB 2017. (15/50164-5)

GUTIERREZ, STEFANIA; BROWN, FEDERICO D.. Vascular budding in Symplegma brakenhielmi and the evolution of coloniality in styelid ascidians. Developmental Biology, v. 423, n. 2, p. 152-169, MAR 15 2017. (15/22650-2, 15/50164-5)

BELATO, FLAVIA A.; MELLO, BEATRIZ; COATES, CHRISTOPHER J.; HALANYCH, KENNETH M.; BROWN, FEDERICO D.; MORANDINI, ANDRE C.; LEME, JULIANA DE MORAES; TRINDADE, RICARDO I. F.; COSTA-PAIVA, ELISA MARIA. Divergence time estimates for the hypoxia-inducible factor-1 alpha (HIF1α) reveal an ancient emergence of animals in low-oxygen environments. Geobiology, v. N/A, p. 14-pg., 2023-09-26. (18/20268-1, 21/14115-0, 19/18051-7, 16/06114-6, 15/50164-5)

HIEBERT, LAUREL S.; SCELZO, MARTA; ALIE, ALEXANDRE; DE TOMASO, ANTHONY W.; BROWN, FEDERICO D.; TIOZZO, STEFANO. Comparing dormancy in two distantly related tunicates reveals morphological, molecular, and ecological convergences and repeated co-option. SCIENTIFIC REPORTS, v. 12, n. 1, p. 17-pg., 2022-07-23. (15/50164-5, 18/05923-3, 18/50017-0)

COSTA-PAIVA, ELISA MARIA; MELLO, BEATRIZ; BEZERRA, BRUNO SANTOS; COATES, CHRISTOPHER J.; HALANYCH, KENNETH M.; BROWN, FEDERICO; LEME, JULIANA DE MORAES; TRINDADE, RICARDO I. F.. Molecular dating of the blood pigment hemocyanin provides new insight into the origin of animals. Geobiology, NOV 2021. (15/50164-5, 18/20268-1, 16/06114-6)

MOREANO-ARROBO, LOLA; PEREZ, OSCAR D.; BROWN, FEDERICO D.; OYARZUN, FERNANDA X.; CANALES-AGUIRRE, CRISTIAN B.. The "Mexican dancer" in Ecuador: molecular confirmation, embryology and planktotrophy in the sea slug Elysia diomedea. INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY, v. 65, n. 4-6, p. 10-pg., 2021-01-01. (19/06927-5, 18/50017-0, 15/50164-5)