Identification and characterization of etiology, mechanisms of damage, neuronal dysfunction, and molecular defects in mesial temporal lobe epilepsy and its relationship with response to treatment

• Grant number: 03/13424-1
• Support Opportunities: Research Projects - Thematic Grants
• Start date: February 01, 2005
• End date: February 28, 2010
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Iscia Teresinha Lopes Cendes
• Grantee: Iscia Teresinha Lopes Cendes
• Host Institution: Faculdade de Ciências Médicas (FCM). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
• Pesquisadores principais: Alexandre Xavier Falcão ; Roberto de Alencar Lotufo ; Roberto José Maria Covolan
• Associated research grant(s): 07/54575-3 - Jayaram K. Udupa | University of Pennsylvania - Estados Unidos, AV.EXT

Abstract

Epilepsy affects approximately 1-2% of the population and partial epilepsies with complex partial seizures account for approximately 40% of all epilepsies in adults. The most frequent form of partial epilepsy in adults is temporal lobe epilepsy (TLE). Classical histopathological studies and, more recently, different high-resolution neuroimaging modalities identify hippocampal atrophy and other signs of hippocampal sclerosis (HS) as the most prominent pathological substrate in patients with intractable mesial temporal lobe epilepsy (MTLE). Our aim is to perform a longitudinal study in a series of patients with MTLE and other forms of partial epilepsies. We will evaluate and quantify structural and functional brain abnormalities, using different modalities of magnetic resonance (MR) imaging, and investigate the relationship between these abnormalities and the genetic substrate using molecular genetic techniques. Specifically, we propose (a) to continue the development of MR techniques for evaluating TLE, including the use of functional MRI with simultaneous EEG recording (EEG-fMRI), (b) to study the relationship between the degree of hippocampal damage determined by MR techniques and anti-epileptic drug (AED) resistance in patients with MTLE, (c) to investigate factors related to prognosis for seizure control in patients submitted to surgical treatment for AED resistant MTLE; (d) to identify and characterize molecular genetic defects in patients with MTLE. We believe that this study will help in better understanding the underlying pathogenic mechanisms in MTLE and other forms of partial epilepsies, and consequently, this may allow a better diagnosis and treatment for these patients. (AU)

Scientific publications

(10)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

MIRANDA, PAULO A. V.; FALCAO, ALEXANDRE X.; ROCHA, ANDERSON; BERGO, FELIPE P. G.. Object delineation by kappa-connected components. EURASIP JOURNAL ON ADVANCES IN SIGNAL PROCESSING, 2008. (03/13424-1, 05/58103-3, 05/56578-4)

BONILHA, LEONARDO; ALESSIO, ANDRÉA; RORDEN, CHRIS; BAYLIS, GORDON; DAMASCENO, BENITO P.; MIN, LI LI; CENDES, FERNANDO. Extrahippocampal gray matter atrophy and memory impairment in patients with medial temporal lobe epilepsy. Human Brain Mapping, v. 28, n. 12, p. 1376-1390, Dec. 2007. (03/13424-1)

AUDIGIER, ROMARIC; LOTUFO, ROBERTO; FALCÃO, ALEXANDRE. 3D visualization to assist iterative object definition from medical images. Computerized Medical Imaging and Graphics, v. 30, n. 4, p. 217-230, June 2006. (03/13424-1)

ALESSIO‚ A.; BONILHA‚ L.; RORDEN‚ C.; KOBAYASHI‚ E.; MIN‚ L.L.; DAMASCENO‚ B.P.; CENDES‚ F.. Memory and language impairments and their relationships to hippocampal and perirhinal cortex damage in patients with medial temporal lobe epilepsy. Epilepsy & Behavior, v. 8, n. 3, p. 593-600, 2006. (03/13424-1)

DE GOES, FERNANDO; BERGO, FELIPE P. G.; FALCAO, ALEXANDRE X.; GOLDENSTEIN, SIOME; VELHO, LUIZ; NETO, MMD; CARCERONI, RL. Adapted dynamic meshes for deformable surfaces. 2009 XXII BRAZILIAN SYMPOSIUM ON COMPUTER GRAPHICS AND IMAGE PROCESSING (SIBGRAPI 2009), v. N/A, p. 3-pg., 2006-01-01. (03/13424-1)

MIRANDA, PAULO A. V.; BERGO, FELIPE P. G.; ROCHA, LEONARDO M.; FALCAO, ALEXANDRE X.; NETO, MMD; CARCERONI, RL. Tree-pruning: A new algorithm and its comparative analysis with the watershed transform for automatic image segmentation. 2009 XXII BRAZILIAN SYMPOSIUM ON COMPUTER GRAPHICS AND IMAGE PROCESSING (SIBGRAPI 2009), v. N/A, p. 2-pg., 2006-01-01. (03/13424-1)

MIRANDA, PAULO A. V.; FALCAO, ALEXANDRE X.; ROCHA, ANDERSON; BERGO, FELIPE P. G.. Object delineation by kappa-connected components. EURASIP JOURNAL ON ADVANCES IN SIGNAL PROCESSING, v. N/A, p. 14-pg., 2008-01-01. (05/56578-4, 05/58103-3, 03/13424-1)

CLÁUDIA VIANNA MAURER-MORELLI; RAFAEL BREGLIO MARCHESINI; RODRIGO SECOLIN; NEIDE FERREIRA SANTOS; ELIANE KOBAYASHI; FERNANDO CENDES; ISCIA LOPES-CENDES. Análise de ligação dos canais de potássio voltagem-dependente na epilepsia de lobo temporal mesial familiar. Arquivos de Neuro-Psiquiatria, v. 65, n. 1, p. 20-23, 2007-03-00. (03/13424-1)

MAURER-MORELLI‚ C. V.; SECOLIN‚ R.; MARCHESINI‚ R. B.; SANTOS‚ N. F.; KOBAYASHI‚ E.; CENDES‚ F.; LOPES-CENDES‚ I.. THE SCN2A gene is not a likely candidate for familial mesial temporal lobe epilepsy. Epilepsy Research, v. 71, n. 2/3, p. 233-236, Oct. 2006. (03/13424-1)

BERGO, FELIPE P. G.; FALCAO, ALEXANDRE X.; IEEE. Fast and automatic curvilinear reformatting of MR images of the brain for diagnosis of dysplastic lesions. 2006 3RD IEEE INTERNATIONAL SYMPOSIUM ON BIOMEDICAL IMAGING: MACRO TO NANO, VOLS 1-3, v. N/A, p. 2-pg., 2006-01-01. (03/13424-1)