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(Reference retrieved automatically from Google Scholar through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

THE SCN2A gene is not a likely candidate for familial mesial temporal lobe epilepsy

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Author(s):
Maurer-Morelli‚ C. V. ; Secolin‚ R. ; Marchesini‚ R. B. ; Santos‚ N. F. ; Kobayashi‚ E. ; Cendes‚ F. ; Lopes-Cendes‚ I.
Total Authors: 7
Document type: Journal article
Source: Epilepsy Research; v. 71, n. 2/3, p. 233-236, Oct. 2006.
Field of knowledge: Health Sciences - Medicine
Abstract

A transgenic mouse model carrying a mutation in the Scn2a gene showed chronic focal seizures associated with extensive cell loss and gliosis in the hippocampus, a similar phenotype found in familial mesial temporal lobe epilepsy (FMTLE). Our objective was to test whether the human homolog of the Scn2a gene is responsible for hippocampal abnormalities in FMTLE by linkage analysis. We conclusively ruled out the SCN2A gene as candidate in FMTLE. (AU)

FAPESP's process: 03/13424-1 - Identification and characterization of etiology, mechanisms of damage, neuronal dysfunction, and molecular defects in mesial temporal lobe epilepsy and its relationship with response to treatment
Grantee:Iscia Teresinha Lopes Cendes
Support type: Research Projects - Thematic Grants