| Full text | |
| Author(s): |
Maurer-Morelli‚ C. V.
;
Secolin‚ R.
;
Marchesini‚ R. B.
;
Santos‚ N. F.
;
Kobayashi‚ E.
;
Cendes‚ F.
;
Lopes-Cendes‚ I.
Total Authors: 7
|
| Document type: | Journal article |
| Source: | Epilepsy Research; v. 71, n. 2/3, p. 233-236, Oct. 2006. |
| Field of knowledge: | Health Sciences - Medicine |
| Abstract | |
A transgenic mouse model carrying a mutation in the Scn2a gene showed chronic focal seizures associated with extensive cell loss and gliosis in the hippocampus, a similar phenotype found in familial mesial temporal lobe epilepsy (FMTLE). Our objective was to test whether the human homolog of the Scn2a gene is responsible for hippocampal abnormalities in FMTLE by linkage analysis. We conclusively ruled out the SCN2A gene as candidate in FMTLE. (AU) | |
| FAPESP's process: | 03/13424-1 - Identificacao e caracterizacao das etiologias, mecanismos de lesao, disfuncao neuronal e defeitos moleculares na epilepsia de lobo temporal mesial e sua relacao com a resposta ao tratamento. |
| Grantee: | Iscia Teresinha Lopes Cendes |
| Support Opportunities: | Research Projects - Thematic Grants |
| FAPESP's process: | 02/10435-0 - Identificacao do gene responsavel pela epilepsia de lobo temporal mesial familial. |
| Grantee: | Cláudia Vianna Maurer Morelli |
| Support Opportunities: | Scholarships in Brazil - Doctorate |