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Investigation of the variation in Copy Number variations using MLPA (Multiplex Ligation- Dependent Probe Amplification) and Arrays in samples of patients with colorectal carcinoma

Abstract

Colorectal cancer (CRC) is the third most common malignant neoplasm worldwide and its etiology is still poorly understood. Several attempts have been made to identify possible genotype-phenotype correlations in CRC, but none has been convincing so far.In this sense, the study of variations in the number of gene copy (Copy Number Variations-CNVs), may contribute to understanding of the causes and development of cancer diseases, and disease resistance. Also, CNVs detection could help to improve the diagnostic and treatment strategies.We propose to use cytogenomic methods such MLPA (Multiplex ligation-dependent probe amplification) and Arrays (Illumina Bead-arrays) to screen for CNVs in a series of samples of patients with CRC from Serviço de Cirurgia Gástrica - FMABC in order to characterize DNA copy number profile and reveal genes that may play an important role in driving the development and outcome of this disease. (AU)

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