| Grant number: | 15/16934-8 |
| Support Opportunities: | Regular Research Grants |
| Start date: | November 01, 2015 |
| End date: | April 30, 2018 |
| Field of knowledge: | Health Sciences - Medicine - Medical Clinics |
| Principal Investigator: | Antonio Carlos Cicogna |
| Grantee: | Antonio Carlos Cicogna |
| Host Institution: | Faculdade de Medicina (FMB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil |
| City of the host institution: | Botucatu |
| Associated researchers: | Katashi Okoshi ; Lucilene Delazari dos Santos |
Abstract
Obesity is a chronic metabolic disease characterized by abnormal or excessive accumulation of fat in relation to lean tissue mass. It is considered a global epidemic caused by multiple factors, being primarily responsible for this pathology sedentary lifestyle combined with excessive food intake. Comorbidities such as, cancer, insulin resistance, type 2 diabetes mellitus, dyslipidemia and cardiovascular diseases are strongly associated with obesity. Studies involving obese humans would be useful in understanding the mechanisms involved in cardiac dysfunction, however, is very difficult to obtain adequate samples, due to various limitations. Therefore, the use of animal models has been increasingly steady in the investigation of the deleterious effects of excess adipose tissue in the heart. This relationship has been examined in obese animals by genetic or dietary manipulations, which latter stands out for being more realistic and more appropriately represent the phenotypic variety of the obese patient. The hyperlipidemic diets are the alternatives used by most research groups to study heart disease due to obesity, however, the results regarding the impact of these diets on the structure and function of the heart are conflicting. Thus, the use of high-fat diet has been questioned, and suggested the use of a diet rich in fats and simple carbohydrates, known as "Western", which can more accurately reproduce the contemporary consumer responsible for the obesity epidemic. The mechanisms related to committal cardiovascular in obesity are not fully elucidated, and studies in this direction is a trend in healthcare. Therewith, one of the research approaches that have been highlighted in the last decade is the proteomic analysis, whose function is to describe the entire set of proteins expressed in a genome under specific conditions and at a given time point, from a cell, tissue or body. Cardiovascular proteomic is one of the most studied areas in the field of proteomic health, however, in models of obesity by diet, it has been little explored, not being found studies that associated cardiac function. Therefore, the aim of this project is to identify myocardial proteins of obese rats by "Western" diet with cardiac dysfunction, using proteomic analysis. With this proposal, we can see which are the proteins that are expressed differently in the myocardium of obese rats with cardiac dysfunction compared to healthy rats, to understand the network of mechanisms involved in heart disease. (AU)
| Articles published in Agência FAPESP Newsletter about the research grant: |
| More itemsLess items |
| TITULO |
| Articles published in other media outlets ( ): |
| More itemsLess items |
| VEICULO: TITULO (DATA) |
| VEICULO: TITULO (DATA) |